Evidence map›Paper›PMID 41686379›Full record

SynthesisSleep & breathing = Schlaf & Atmung2026

Prevalence of coronary atherosclerosis in patients with obstructive sleep apnea syndrome: a systematic review and meta-analysis.

Ling Lin, Daping Wei, Fuqun Mao, Yan Qiao, Ling Zhong, Xuerui Wu, Li Ge, Chao Wu, Xin Shen

Abstract readSystematic ReviewMeta-Analysis
PubMed Publisher
In one paragraph

Synthesis in Sleep & breathing = Schlaf & Atmung, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ling LinDepartment of neurology, The Fourth People's Hospital of Chengdu, No. 8, Huli West First Lane, Jinniu District, Cheng Du, 610036, China. 261072444@qq.com.ORCID 0009-0003-5797-2310
Daping WeiDepartment of neurology, The Fourth People's Hospital of Chengdu, No. 8, Huli West First Lane, Jinniu District, Cheng Du, 610036, China.
Fuqun MaoDepartment of neurology, The Fourth People's Hospital of Chengdu, No. 8, Huli West First Lane, Jinniu District, Cheng Du, 610036, China.
Yan QiaoDepartment of neurology, The Fourth People's Hospital of Chengdu, No. 8, Huli West First Lane, Jinniu District, Cheng Du, 610036, China.
Ling ZhongDepartment of neurology, The Fourth People's Hospital of Chengdu, No. 8, Huli West First Lane, Jinniu District, Cheng Du, 610036, China.
Xuerui WuDepartment of neurology, The Fourth People's Hospital of Chengdu, No. 8, Huli West First Lane, Jinniu District, Cheng Du, 610036, China.
Li GeDepartment of neurology, The Fourth People's Hospital of Chengdu, No. 8, Huli West First Lane, Jinniu District, Cheng Du, 610036, China.
Chao WuDepartment of neurology, The Fourth People's Hospital of Chengdu, No. 8, Huli West First Lane, Jinniu District, Cheng Du, 610036, China.
Xin ShenDepartment of neurology, The Fourth People's Hospital of Chengdu, No. 8, Huli West First Lane, Jinniu District, Cheng Du, 610036, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundObstructive sleep apnea (OSA) syndrome is a common sleep-related breathing disorder characterized by recurrent episodes of upper airway collapse during sleep. Coronary atherosclerosis, a significant cause of cardiovascular morbidity and mortality worldwide, has been associated with OSA in several studies. However, the precise nature and magnitude of this association remain incompletely defined. This study sought to systematically evaluate the available evidence and quantify the relationship between OSA and coronary atherosclerosis through meta-analysis.

methodA systematic literature review across PubMed, Embase, Cochrane Library, and Web of Science databases was conducted from inception through September 3, 2024. Two investigators performed independent literature screening, data extraction, and quality assessment of included studies. Statistical assessment was performed using Stata 18.

resultsAnalysis of 11 studies encompassing 6587 participants revealed that the overall prevalence of coronary atherosclerosis within the OSA patients was 46% (95% CI: 32%-60%; I2 = 98.5%; P < 0.001). Subgroup analysis demonstrated that coronary atherosclerosis prevalence increased proportionally with OSA severity: 33% (95% CI: 9%-57%; I2 = 99.2%; P < 0.001) in mild OSA, 58% (95% CI: 47%-70%; I2 = 68.4%; P = 0.024) in moderate OSA, and 68% (95% CI: 61%-76%; I2 = 57.2%; P = 0.053) in severe OSA, with an overall prevalence across all severity categories of 50% (95% CI: 34%-66%; P < 0.001).

conclusionThe analysis demonstrates that OSA is associated with an elevated risk of coronary atherosclerosis, with prevalence increasing in parallel with disease severity, it was only demonstrated in observational studies, but not in RCTs.

Indexed as

Coronary Artery DiseaseSleep Apnea, ObstructiveComorbidityHumansPrevalenceCoronary atherosclerosisMeta-analysisObstructive sleep apnea syndromePrevalence

Identifiers

PMID41686379

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.