ArticleSleep & breathing = Schlaf & Atmung2026
Sleep in MELAS syndrome.
Article in Sleep & breathing = Schlaf & Atmung, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Sleep performance in MELAS is related not only to the syndrome, but also to several other endogenous and exogenous determinants.Sleep & breathing = Schlaf & Atmung · 2026Article
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5 authors.
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Abstract
The syndrome of mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes (MELAS) is one of the most frequent maternally inherited mitochondrial disorders, and presents numerous clinical manifestations such us stroke-like episodes, dementia, epilepsy, myopathy, headaches, hearing impairment or diabetes. Little attention has been paid to the possible influence of sleep disorders on this pathology. We conducted subjective and objective assessments of sleep in patients with MELAS syndrome, focusing on sleep-disordered breathing and REM sleep behavior disorder (RBD). We obtained a total of 7 cases with a complete analyzable nocturnal PSG study and expanded the study by reviewing the PSGs performed on patients with MELAS-type mitochondrial disease in recent years, reaching a total of 18 cases. Results showed the presence of obstructive sleep apnea (OSA) in 83% of cases, along with parameters that indicated poor sleep quality in these patients. We did not observe any cases of RBD or central apnea (CSA). In conclusion, this work reinforces the need for evaluation of patients with mitochondrial disease by a sleep specialist, as well as carrying out studies aimed at diagnosing possible sleep disorders, which could modify the treatment and quality of life of these subjects.
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