Evidence map›Paper›PMID 41686282›Full record

ArticleSleep & breathing = Schlaf & Atmung2026

Evaluation of apelin, chemerin, leptin, resistin and vaspin levels in patients with obstructive sleep apnoea syndrome.

Eren Kirdar Ozturk, Merve Akis Yilmaz, Nurhan Sarioglu, A Adil Hismiogullari

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Article in Sleep & breathing = Schlaf & Atmung, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

4 authors.

Eren Kirdar OzturkMedicine Faculty, Department of Biochemistry, Balikesir University, Balikesir, Türkiye.
Merve Akis YilmazMedicine Faculty, Department of Biochemistry, Balikesir University, Balikesir, Türkiye.
Nurhan SariogluMedicine Faculty, Department of Pulmonary Medicine, Balikesir University, Balikesir, Türkiye.
A Adil HismiogullariMedicine Faculty, Department of Biochemistry, Balikesir University, Balikesir, Türkiye. hismiogullari@balikesir.edu.tr.

Funding

Balikesir Üniversitesi Project number: BAP 2017/062
6 · The paper itself

Abstract

backgroundThe aim of this study was to investigate serum levels of apelin, chemerin, leptin, resistin, vaspin and advanced glycation end-products (AGEs) relationships with Obstructive Sleep Apnea Syndrome (OSA).

methods54 OSA patients and 34 healthy controls participated in this study. The levels of chemerin, leptin, resistin, vaspin and AGEs were determined in the serum by the ELISA method.

resultsThe chemerin median values were significantly higher (p = 0,012) in the patients group when compared with the control. In contrast, the mean of AGEs in the patient’s group was significantly decreased compared to the control group (p = 0.036). A positive correlation was found between chemerin and apnea-hypopnea index (AHI) (r = 304, p = 0.025) and oxygen desaturation index (ODI) (r = 0.278, p = 0.042). A correlation was also observed among chemerin and haemoglobin (r = 0.228, p = 0.032) and iron (r = 0.339, p = 001). There was a positive correlation between apelin and C-reactive protein (CRP) (r = 0.226, p = 0.034). Leptin was positively correlated with body mass index (BMI), glucose, insulin, HbA1c, haemoglobin and iron.

conclusionsThe result of this study demonstrate that chemerin and AGEs are related to OSA physiopathology. These two parameters may help in the diagnosis and progress of sleep apnea.

Indexed as

ApelinChemokinesIntercellular Signaling Peptides and ProteinsLeptinResistinSerpinsSleep Apnea, ObstructiveAdultFemaleGlycation End Products, AdvancedHumansMaleMiddle AgedPolysomnographyApelinChemokinesGlycation End Products, AdvancedIntercellular Signaling Peptides and ProteinsLeptinRARRES2 protein, humanResistinSERPINA12 protein, humanSerpinsApelinChemerinLeptinObstructive sleep apneaResistinVaspin

Identifiers

PMID41686282

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.