ArticlePediatric radiology2026
Diagnostic and management challenge of a pediatric H3K27-altered glioma masquerading as vestibular schwannoma.
Article in Pediatric radiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Pediatric H3K27-altered glioma most frequently arises from midline cerebral parenchyma, whereas intracranial extra-axial locations are exceedingly rare. We report the case of an 8-year-old boy who presented with chronic-onset left-sided hearing impairment and peripheral facial paralysis. Radiological imaging identified an isolated cerebellopontine angle lesion distinct from surrounding structures. A vestibular schwannoma was diagnosed based on preoperative examinations. Surgical resection revealed an unusual facial nerve-infiltrating mass with distinct vascular features. Histopathological assessment yielded an unexpected diagnosis of H3K27-altered diffuse midline glioma, contrasting with initial preoperative impressions. This exceptional case illustrates diagnostic pitfalls in pediatric skull base pathologies and expands the recognized spectrum of diffuse midline gliomas.
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