Evidence map›Paper›PMID 41685947›Full record

ArticleJournal of gastroenterology and hepatology2026

Impact of Diet and Drugs on Fecal Lachnoclostridium Gene Marker (m3) in Non-Invasive Diagnosis of Colorectal Neoplasia.

Min Dai, Louis H S Lau, Haiyun Shi, Yang Sun, Xiaobo Li, Mengbin Li, Hui Wang, Raphaela I Lau, Jessie Q Y Liang, Francis K L Chan and 1 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of gastroenterology and hepatology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Min DaiMicrobiota I-Center (MagIC), Shatin, Hong Kong SAR, China.ORCID https://orcid.org/0000-0002-7502-685X
Louis H S LauDepartment of Medicine and Therapeutics, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China.ORCID https://orcid.org/0000-0002-4163-4531
Haiyun ShiDepartment of Gastroenterology, Beijing Friendship Hospital, Capital Medical University, National Clinical Research Center for Digestive Disease, Beijing Digestive Disease Center, State Key Laboratory of Digestive Health, Beijing, China.ORCID https://orcid.org/0000-0002-2084-8370
Yang SunDepartment of Gastroenterology, The First Affiliated Hospital of Kunming Medical University, Yunnan Province Clinical Research Center for Digestive Disease, Yunnan Geriatric Medical Center, Kunming, China.
Xiaobo LiDivision of Gastroenterology and Hepatology, Shanghai Institute of Digestive Disease, NHC Key Laboratory of Digestive Diseases, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.ORCID https://orcid.org/0000-0002-5206-6445
Mengbin LiDepartment of Digestive Surgery, Xijing Hospital of Digestive Diseases, Air Force Medical University, Xi'an, China.
Hui WangGuangdong Institute of Gastroenterology, Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Raphaela I LauMicrobiota I-Center (MagIC), Shatin, Hong Kong SAR, China.
Jessie Q Y LiangDepartment of Medicine and Therapeutics, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China.ORCID https://orcid.org/0000-0001-8496-3442
Francis K L ChanMicrobiota I-Center (MagIC), Shatin, Hong Kong SAR, China.
Siew C NgMicrobiota I-Center (MagIC), Shatin, Hong Kong SAR, China.ORCID https://orcid.org/0000-0002-6850-4454

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundA novel bacterial gene marker, Lachnoclostridium (m3), has potential for non-invasive diagnosis of colorectal cancer (CRC) and adenoma.

aimThis study aims to determine the diagnostic performance of m3 in a multi-center cohort and to examine the effect of diet and drugs on fecal m3 in subjects with colorectal neoplasia.

methodsIn a prospective cohort study, we included 2563 subjects (330 CRC, 1119 adenomas, and 1114 controls) from two independent cohorts from Hong Kong and five cities in the Chinese mainland. Stool samples were collected before colonoscopies and bowel preparation. Dietary information was collected using a qualitative dietary questionnaire. Fecal m3 was measured using quantitative PCR (qPCR). Receiver operating characteristic (ROC) curves were used to evaluate the diagnostic performance of fecal m3. The impact of diet and drugs on fecal m3 was investigated using in vitro experiments and multivariate analysis by logistic regression.

resultsFecal m3 could significantly discriminate CRC and advanced adenoma (AA) from normal controls, with areas under the receiver operating characteristic curve (AUROC) of 0.701 and 0.604 (both p < 0.001), respectively. Three types of dietary components (meat, vegetables, and oil) and 15 drugs did not affect fecal m3 levels in vitro. In multivariate analysis, after adjusting for clinical factors, diet and drugs did not have a significant impact on fecal m3 levels in subjects with colorectal neoplasia.

conclusionFecal m3 levels and diagnostic performance were not influenced by diet and drugs. It can be considered a promising and reliable non-invasive diagnostic biomarker for colorectal neoplasia.

Indexed as

ActinobacteriaAdenomaBiomarkers, TumorColorectal NeoplasmsDietFecesAgedCohort StudiesFemaleGenetic MarkersHumansMaleMiddle AgedProspective StudiesROC CurveBiomarkers, TumorGenetic Markersbiomarkercolorectal neoplasiadietdrugLachnoclostridium

Identifiers

PMID41685947
PMCPMC13058778

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.