ArticleMicrobiology spectrum2026
Comparative impacts of normobaric vs. hypobaric hypoxia on tissue integrity and gut microbiota in acute high-altitude murine models.
Article in Microbiology spectrum, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- FMT and Bifidobacterium quadruple viable tablets supplementation modulate gut microbiota to ameliorate high-altitude exposure induced colonic injury.Frontiers in microbiology · 2026Article
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Authors and funding
13 authors.
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Abstract
Normobaric hypoxia (NH) and hypobaric hypoxia (HH) are the two primary approaches currently used to establish high-altitude animal models in lowland laboratories. However, their relative suitability and effectiveness remain debated. This study conducts a comparative assessment of acute high-altitude models generated under NH and HH, specifically comparing their impacts on gut microbiota. Mice from the same batch were exposed to NH or HH conditions equivalent to 5,500 m in a high-altitude simulation chamber. After 72 h of exposure, tissue samples were collected. Histopathological analyses showed that HH caused more severe tissue injury than NH across multiple organs, particularly the lung, liver, hepatic lobule, and prefrontal cortex. Additionally, 16S rRNA sequencing characterized changes in gut microbiota structure, composition, differentially abundant taxa, and predicted functional profiles. These analyses revealed distinct gut microbiota structure between the two hypoxic conditions. The HH group showed a greater increase in Bacillota and a more pronounced decrease in Bacteroidota, along with a higher abundance of
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