ArticleCancer medicine2026
Rapid and Accurate Diagnosis of Breast Cancer by Fine-Needle Aspiration Biopsy Using the "Click-to-Sense" Method.
Article in Cancer medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Rapid and Accurate Diagnosis of Breast Cancer by Fine-Needle Aspiration Biopsy Using the "Click-to-Sense" Method.Cancer medicine · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
18 authors.
Funding
Abstract
backgroundWe have previously demonstrated the value of the "click-to-sense" (CTS) assay, in which a fluorescent probe targeting acrolein can detect cancer cells and differentiate between malignant and benign lesions in breast tissue. In this study, we assessed the usefulness of the CTS assay for diagnosis of breast tumors by fine-needle aspiration biopsy (FNAB).
methodsA total of 126 FNABs were performed on live tissue samples obtained by surgery (63 breast cancers, 31 benign breast tumors, and 32 normal breast glands). CTS reagents (CTS probe and Hoechst dye mixed with encapsulating agents) were added to the aspirated cells and placed on slides, which were then cover-slipped and imaged under a fluorescence microscope. Another FNAB slide was prepared for each of the same live tissue samples, fixed in ethanol, and subjected to Papanicolaou (PAP) staining. The diagnostic accuracy of the CTS assay was compared with that of PAP staining by histopathological examination of permanent sections.
resultsThe CTS assay had a sensitivity of 92.1%, a specificity of 96.8%, and an accuracy of 94.4% (119/126 samples); the respective values for PAP staining were 98.4%, 89.8%, and 94.2% (114/121 samples). The insufficiency/inadequacy rate was 0% for the CTS assay and 4% for PAP staining (5/126 samples).
conclusionThe CTS assay is as accurate as PAP staining for FNAB of breast lesions. This assay has the potential to establish a new diagnostic method in cytopathology in the future, because it has a lower inadequacy rate and is simpler and less labor-intensive and time-consuming to perform.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.