Evidence map›Paper›PMID 41685883›Full record

ArticleAging cell2026

Telomere Shortening Drives Atrial Fibrillation Through VCAM-1 Mediated Atrial Electrical and Structural Remodeling.

Zhaojia Wang, Rui Zhao, Yuwen Wang, Nan Zhang, Qiuhui Yang, Zandong Zhou, Duo Jiang, Xu Zhang, Jinghua Yuan, Yi Zheng and 8 more

Abstract read
In one paragraph

Article in Aging cell, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Zhaojia WangTianjin Key Laboratory of Ion and Molecular Function of Cardiovascular Diseases, Department of Cardiology, Second Hospital of Tianjin Medical University, Tianjin Institute of Cardiology, Tianjin, China.
Rui ZhaoDepartment of Genetics, School of Basic Medical Science, Tianjin Medical University, The Province and Ministry Co-Sponsored Collaborative Innovation Center for Medical Epigenetics, Tianjin, People's Republic of China.
Yuwen WangDepartment of Genetics, School of Basic Medical Science, Tianjin Medical University, The Province and Ministry Co-Sponsored Collaborative Innovation Center for Medical Epigenetics, Tianjin, People's Republic of China.
Nan ZhangTianjin Key Laboratory of Ion and Molecular Function of Cardiovascular Diseases, Department of Cardiology, Second Hospital of Tianjin Medical University, Tianjin Institute of Cardiology, Tianjin, China.
Qiuhui YangDepartment of Genetics, School of Basic Medical Science, Tianjin Medical University, The Province and Ministry Co-Sponsored Collaborative Innovation Center for Medical Epigenetics, Tianjin, People's Republic of China.
Zandong ZhouTianjin Key Laboratory of Ion and Molecular Function of Cardiovascular Diseases, Department of Cardiology, Second Hospital of Tianjin Medical University, Tianjin Institute of Cardiology, Tianjin, China.
Duo JiangDepartment of Genetics, School of Basic Medical Science, Tianjin Medical University, The Province and Ministry Co-Sponsored Collaborative Innovation Center for Medical Epigenetics, Tianjin, People's Republic of China.
Xu ZhangTianjin Key Laboratory of Ion and Molecular Function of Cardiovascular Diseases, Department of Cardiology, Second Hospital of Tianjin Medical University, Tianjin Institute of Cardiology, Tianjin, China.
Jinghua YuanDepartment of Genetics, School of Basic Medical Science, Tianjin Medical University, The Province and Ministry Co-Sponsored Collaborative Innovation Center for Medical Epigenetics, Tianjin, People's Republic of China.
Yi ZhengTianjin Key Laboratory of Ion and Molecular Function of Cardiovascular Diseases, Department of Cardiology, Second Hospital of Tianjin Medical University, Tianjin Institute of Cardiology, Tianjin, China.
Wenhua SongTianjin Key Laboratory of Ion and Molecular Function of Cardiovascular Diseases, Department of Cardiology, Second Hospital of Tianjin Medical University, Tianjin Institute of Cardiology, Tianjin, China.
Daiqi LiuTianjin Key Laboratory of Ion and Molecular Function of Cardiovascular Diseases, Department of Cardiology, Second Hospital of Tianjin Medical University, Tianjin Institute of Cardiology, Tianjin, China.
Xunzhi LiuShanghai Fuyang Biotechnology Co., LTD, Shanghai, China.
Kejing YuanShanghai Fuyang Biotechnology Co., LTD, Shanghai, China.
Gary TseTianjin Key Laboratory of Ion and Molecular Function of Cardiovascular Diseases, Department of Cardiology, Second Hospital of Tianjin Medical University, Tianjin Institute of Cardiology, Tianjin, China.
Gregory Y H LipTianjin Key Laboratory of Ion and Molecular Function of Cardiovascular Diseases, Department of Cardiology, Second Hospital of Tianjin Medical University, Tianjin Institute of Cardiology, Tianjin, China.ORCID 0000-0002-7566-1626
Tong LiuTianjin Key Laboratory of Ion and Molecular Function of Cardiovascular Diseases, Department of Cardiology, Second Hospital of Tianjin Medical University, Tianjin Institute of Cardiology, Tianjin, China.
Feng WangDepartment of Genetics, School of Basic Medical Science, Tianjin Medical University, The Province and Ministry Co-Sponsored Collaborative Innovation Center for Medical Epigenetics, Tianjin, People's Republic of China.

Funding

CAMS innovation Fund for Medical Sciences 2021-I2M-1-042CAMS innovation Fund for Medical Sciences 2022-I2M-2-003CAMS innovation Fund for Medical Sciences 2022-I2M-2-008National Natural Science Foundation of China 31771520National Natural Science Foundation of China 32170762National Natural Science Foundation of China 82072331National Natural Science Foundation of China 82170327National Natural Science Foundation of China 82271265National Natural Science Foundation of China 82370332National Natural Science Foundation of China 92149302Natural Science Foundation of Tianjin city 19JCJQJC63500Natural Science Foundation of Tianjin city 23JCZDJC00270Natural Science Foundation of Tianjin city 24JCQNJC00820Natural Science Foundation of Tianjin city 25JCZDJC00510Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences 2025-JKCS-23Scientific Research Program of Tianjin Municipal Education Commission 2023KJ038Scientific Research Program of Tianjin Municipal Education Commission 2020KJ200 and the Tianjin Health Research Project 19YFZCSY00600
6 · The paper itself

Abstract

Telomere shortening is a hallmark of aging and has been implicated in cardiovascular disease, but its mechanistic link to atrial fibrillation (AF) remains elusive. Using a high-throughput, single-gene-calibrated dot blot assay, we developed to quantify leukocyte telomere length (LTL). In age-stratified analyses, shorter LTL was associated with AF predominantly in individuals younger than 70 years. In telomerase-deficient (TERT

Indexed as

Atrial FibrillationAtrial RemodelingHeart AtriaTelomere ShorteningVascular Cell Adhesion Molecule-1AnimalsHumansMiceVascular Cell Adhesion Molecule-1agingatrial fibrillationtelomereTERTVCAM‐1

Identifiers

PMID41685883
PMCPMC12903549

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.