Evidence map›Paper›PMID 41685881›Full record

ArticleBiomacromolecules2026

Chiral Glass Formation by Dipeptide Salts.

Valeria Castelletto, Ian W Hamley

Abstract read
In one paragraph

Article in Biomacromolecules, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Valeria CastellettoSchool of Chemistry, Food Biosciences and Pharmacy, University of Reading, Whiteknights, Reading RG6 6AD, U.K.ORCID 0000-0002-3705-0162
Ian W HamleySchool of Chemistry, Food Biosciences and Pharmacy, University of Reading, Whiteknights, Reading RG6 6AD, U.K.ORCID 0000-0002-4549-0926

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A simple dipeptide WR (tryptophan-arginine) in the form of salts with organic acids tartaric acid or crotonic acid is shown to form glasses through a benign preparation route by evaporation of aqueous solution. The glasses have a remarkable range of properties including moldability, high transparency across a broad range of wavelengths, and fluorescence. The glasses show self-healing and adhesive properties, and have accessible glass transition temperatures. The glasses are shown to be amorphous via small-angle and wide-angle X-ray scattering (SAXS/WAXS) and scanning electron microscopy (SEM). Remarkably, the glasses are found to have a chiral structure, as shown by circular dichroism (CD) spectroscopy. Investigation of glass precursor dipeptide salt solutions shows that the glasses form from an initial unordered solution containing chiral peptide molecules. The diverse properties of the dipeptide glass materials points to a wide range of potential future applications.

Indexed as

DipeptidesGlassCircular DichroismMicroscopy, Electron, ScanningSaltsStereoisomerismX-Ray DiffractionDipeptidesSalts

Identifiers

PMID41685881
PMCPMC12977033

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.