ReviewEuropean endodontic journal2025
Internally Heated Sodium Hypochlorite for Endodontic Irrigation: A Narrative Review of Efficacy and Clinical Applicability.
Review in European endodontic journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Outcomes and Associated Prognostic Factors for Orthograde Canal Obturation Using Ortho MTA III: A Randomised Prospective Clinical Trial.International endodontic journal · 2026Trial
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Endodontic therapy aims to reduce the microbial load within the root canal system to a level manageable by the host's innate defence mechanisms. Both the shaping and irrigation phases are critical determinants of treatment success. Sodium hypochlorite (NaOCl) remains the irrigant of choice owing to its potent tissue-dissolving and antimicrobial properties. To enhance the efficacy of NaOCl, various activation techniques have been proposed, including manual agitation, sonic and ultrasonic activation, as well as thermal enhancement. Notably, the internal heating of NaOCl to temperatures approaching its boiling point has been shown to increase its chemical reactivity by up to 200-fold. An electronic literature search was undertaken using three databases: PubMed, Scopus, and Web of Science. The following keywords were employed: ('irrigant' OR 'NaOCl' OR 'sodium hypochlorite') AND ('heating' OR 'pre-heating' OR 'warming' OR 'heat activation'). After the removal of duplicate records and the exclusion of irrelevant titles and abstracts, the remaining studies were screened for eligibility. A total of 226 records were identified: 110 from PubMed, 98 from Scopus, and 18 from Web of Science. Following the removal of 33 duplicate entries, 193 records remained for initial screening. Of these,153 were excluded for not meeting the inclusion criteria. The full texts of the remaining 40 articles were retrieved and assessed in detail. Twenty-one studies met the inclusion criteria. Collectively, these studies indicated that internal heating of NaOCl enhanced its antibacterial efficacy, accelerated the dissolution of organic tissues, and improved smear layer removal, all while remaining compatible with conservative root canal shaping protocols. Owing to its simplicity, cost-effectiveness, and ease of implementation within routine clinical protocols, the internal heating of sodium hypochlorite represents a promising adjunct in endodontic irrigation. This technique has the potential to improve treatment predictability and enhance patient outcomes. (EEJ-2025-04-065).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.