ArticleBioconjugate chemistry2026
Efficient Inhibition of TGF-β Signaling via Cytosolic Delivery of a Smad2/3-Binding Peptide Using the Cell-Penetrating PG-Surfactant
Ryunosuke Suzuki, Nanami Kono, Riku Kawasaki, Yasumichi Inoue, Momoka Yamada, Toyohiro Imai, Naoki Umezawa, Atsushi Ikeda, Shinya Tsukiji, Toshihisa Mizuno
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In one paragraphArticle in Bioconjugate chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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10 authors.
Ryunosuke SuzukiDepartment of Life Science and Applied Chemistry, Graduate School of Engineering, Nagoya Institute of Technology, Gokiso-cho, Showa-ku, Nagoya, Aichi 466-8555, Japan.
Nanami KonoProgram of Applied Chemistry, Graduate School of Advanced Science and Engineering, Hiroshima University, Higashi, Hiroshima 739-8527, Japan.
Riku KawasakiProgram of Applied Chemistry, Graduate School of Advanced Science and Engineering, Hiroshima University, Higashi, Hiroshima 739-8527, Japan.
Yasumichi InoueGraduate School of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabe-dori, Mizuho-ku, Nagoya 467-8603, Japan.
Momoka YamadaDepartment of Life Science and Applied Chemistry, Graduate School of Engineering, Nagoya Institute of Technology, Gokiso-cho, Showa-ku, Nagoya, Aichi 466-8555, Japan.
Toyohiro ImaiDepartment of Life Science and Applied Chemistry, Graduate School of Engineering, Nagoya Institute of Technology, Gokiso-cho, Showa-ku, Nagoya, Aichi 466-8555, Japan.
Naoki UmezawaGraduate School of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabe-dori, Mizuho-ku, Nagoya 467-8603, Japan.ORCID 0000-0003-3966-2303 Atsushi IkedaProgram of Applied Chemistry, Graduate School of Advanced Science and Engineering, Hiroshima University, Higashi, Hiroshima 739-8527, Japan.ORCID 0000-0003-3492-3455 Shinya TsukijiDepartment of Life Science and Applied Chemistry, Graduate School of Engineering, Nagoya Institute of Technology, Gokiso-cho, Showa-ku, Nagoya, Aichi 466-8555, Japan.ORCID 0000-0002-1402-5773 Toshihisa MizunoDepartment of Life Science and Applied Chemistry, Graduate School of Engineering, Nagoya Institute of Technology, Gokiso-cho, Showa-ku, Nagoya, Aichi 466-8555, Japan.ORCID 0000-0002-6878-5911 Funding
No grant is acknowledged in the PubMed record.
6 · The paper itselfAbstract
Targeting intracellular signaling molecules that translocate to the nucleus is a promising approach for peptide-based therapeutics. Here, we focused on Smad2/3, key mediators of TGF-β signaling that act as transcription factors upon nuclear entry. To inhibit their nuclear localization, we delivered an Smad2/3-binding SARA peptide into the cytoplasm using our previously developed cell-penetrating carrier, cpPG. A conjugate, SARA-cpPG, was synthesized by linking the SARA peptide to
Indexed as
Cell NucleusCell-Penetrating PeptidesCytosolSignal TransductionSmad2 ProteinSmad3 ProteinTransforming Growth Factor betaA549 CellsActive Transport, Cell NucleusHumansCell-Penetrating PeptidesSmad2 ProteinSMAD2 protein, humanSmad3 ProteinSMAD3 protein, humanTransforming Growth Factor beta
Identifiers
PMID41685736
PMCPMC13003443
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