Evidence map›Paper›PMID 41685593›Full record

ArticleMolecular medicine reports2026

ULK1 activates NCOA4‑mediated ferritinophagy via the Beclin1/VPS34 complex in cardiomyocyte hypertrophy.

Qianhui Zhang, Meitian Zhang, Yongsheng Liu, Pilong Shi, Hanping Qi, Man Jiang, Yonggang Cao, Hongli Sun

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular medicine reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Qianhui Zhang *Department of Pharmacology, Harbin Medical University, Daqing, Heilongjiang 163319, P.R. China.
Meitian Zhang *Department of Pharmacology, Harbin Medical University, Daqing, Heilongjiang 163319, P.R. China.
Yongsheng LiuDepartment of Pharmacology, Harbin Medical University, Daqing, Heilongjiang 163319, P.R. China.
Pilong ShiDepartment of Pharmacology, Harbin Medical University, Daqing, Heilongjiang 163319, P.R. China.
Hanping QiDepartment of Pharmacology, Harbin Medical University, Daqing, Heilongjiang 163319, P.R. China.
Man JiangDepartment of Pharmacology, Harbin Medical University, Daqing, Heilongjiang 163319, P.R. China.
Yonggang CaoDepartment of Pharmacology, Harbin Medical University, Daqing, Heilongjiang 163319, P.R. China.
Hongli SunDepartment of Pharmacology, Harbin Medical University, Daqing, Heilongjiang 163319, P.R. China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cardiac hypertrophy is associated with ferroptosis. Serine/threonine protein kinase ULK1 (ULK1) acts as a key activator of autophagy; however, its exact function in the non‑autophagy pathway remains to be fully elucidated. The present study aimed to decipher the role and mechanisms of ULK1 in ferroptosis and cardiomyocyte hypertrophy. Cell survival, lipid peroxidation, iron metabolism and prostaglandin endoperoxide synthase 2 (

Indexed as

AutophagyAutophagy-Related Protein-1 HomologBeclin-1CardiomegalyClass III Phosphatidylinositol 3-KinasesIntracellular Signaling Peptides and ProteinsMyocytes, CardiacNuclear Receptor CoactivatorsAnimalsCell LineCyclooxygenase 2FerroptosisIronLipid PeroxidationMiceRatsAutophagy-Related Protein-1 HomologBeclin-1Class III Phosphatidylinositol 3-KinasesCyclooxygenase 2Intracellular Signaling Peptides and ProteinsIronNuclear Receptor CoactivatorsPtgs2 protein, ratULK1 protein, ratautophagyBeclin1ferritinophagyferroptosisULK1

Identifiers

PMID41685593
PMCPMC12963816

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.