Evidence map›Paper›PMID 41685583›Full record

ArticleMolecular medicine reports2026

Puerarin attenuates myocardial ischemia‑reperfusion injury by inhibiting myocardium pyroptosis via the NRF2/HO‑1 signaling pathway.

Xiaoyu Zheng, Jinping Li, Tianyang Hu, Li Tan, Ding Lan, Ying Deng

Abstract read
In one paragraph

Article in Molecular medicine reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Xiaoyu ZhengDepartment of Cardiovascular and Cerebrovascular Diseases, School of Clinical Medicine, Chongqing Medical and Pharmaceutical College, Chongqing 401331, P.R. China.
Jinping LiDepartment of Science and Education, The First People's Hospital of Zhaotong City and Zhaotong Hospital Affiliated to Kunming Medical University, Zhaotong, Yunnan 657000, P.R. China.
Tianyang HuDepartment of Precision Medicine Center, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, P.R. China.
Li TanDepartment of Cardiovascular and Cerebrovascular Diseases, School of Clinical Medicine, Chongqing Medical and Pharmaceutical College, Chongqing 401331, P.R. China.
Ding LanDepartment of Cardiovascular and Cerebrovascular Diseases, School of Clinical Medicine, Chongqing Medical and Pharmaceutical College, Chongqing 401331, P.R. China.
Ying DengDepartment of Cardiology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, P.R. China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Myocardial ischemia‑reperfusion injury (MIRI) can trigger inflammatory responses and cause pyroptosis. Puerarin (Pue), as a traditional medicine, exhibits potential value in cardiac protection. However, the mechanism by which Pue regulates pyroptosis in MIRI remains to be fully elucidated. The present study aimed to explore the cardioprotective effects of Pue against MIRI and reveal the underlying mechanisms of these effects. Sprague‑Dawley rats were used to establish

Indexed as

Heme Oxygenase-1IsoflavonesMyocardial Reperfusion InjuryNF-E2-Related Factor 2PyroptosisSignal TransductionAnimalsCell LineHeme Oxygenase (Decyclizing)MaleMyocardiumMyocytes, CardiacRatsRats, Sprague-DawleyHeme Oxygenase-1Heme Oxygenase (Decyclizing)Hmox1 protein, ratIsoflavonesNfe2l2 protein, ratNF-E2-Related Factor 2puerarinheme oxygenase‑1inflammationmyocardial ischemia‑reperfusion injurynuclear factor E2‑related factor 2puerarinpyroptosis

Identifiers

PMID41685583
PMCPMC12930366

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.