Evidence map›Paper›PMID 41685536›Full record

ArticleJournal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc2026

Detection of highly pathogenic avian influenza A(H5N1) clade 2.3.4.4b virus in cull dairy cows with underlying respiratory and systemic disease.

Daniel J Righter, Erin B Howey, Chris L Siepker, Eric R Burrough, Drew R Magstadt, Marta Mainenti, Asha Fears, Aaron D Lehmkuhl, Gleeson Murphy, Kimberly Lehman and 3 more

Abstract read
In one paragraph

Article in Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Detection of highly pathogenic avian influenza A(H5N1) virus, clade 2.3.4.4b, genotype B3.13 in placentas from aborted bovine fetuses.Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Daniel J RighterFood Safety and Inspection Service, U.S. Department of Agriculture, Athens, GA, USA.ORCID 0009-0002-1261-8986
Erin B HoweyFood Safety and Inspection Service, U.S. Department of Agriculture, Athens, GA, USA.ORCID 0000-0003-0912-6518
Chris L SiepkerCollege of Veterinary Medicine, Iowa State University, Ames, IA, USA.ORCID 0000-0001-8590-046X
Eric R BurroughCollege of Veterinary Medicine, Iowa State University, Ames, IA, USA.ORCID 0000-0003-4747-9189
Drew R MagstadtCollege of Veterinary Medicine, Iowa State University, Ames, IA, USA.
Marta MainentiCollege of Veterinary Medicine, Iowa State University, Ames, IA, USA.ORCID 0000-0001-8967-0016
Asha FearsFood Safety and Inspection Service, U.S. Department of Agriculture, Athens, GA, USA.
Aaron D LehmkuhlNational Veterinary Services Laboratories, National Centers for Animal Health, Animal and Plant Health Inspection Service, U.S. Department of Agriculture, Ames, IA.
Gleeson MurphyNational Veterinary Services Laboratories, National Centers for Animal Health, Animal and Plant Health Inspection Service, U.S. Department of Agriculture, Ames, IA.
Kimberly LehmanNational Veterinary Services Laboratories, National Centers for Animal Health, Animal and Plant Health Inspection Service, U.S. Department of Agriculture, Ames, IA.ORCID 0000-0003-2795-988X
Mia Kim TorchettiNational Veterinary Services Laboratories, National Centers for Animal Health, Animal and Plant Health Inspection Service, U.S. Department of Agriculture, Ames, IA.
Suelee Robbe-AustermanNational Veterinary Services Laboratories, National Centers for Animal Health, Animal and Plant Health Inspection Service, U.S. Department of Agriculture, Ames, IA.ORCID 0000-0002-3794-3040
Carrie E SchmidtFood Safety and Inspection Service, U.S. Department of Agriculture, Athens, GA, USA.ORCID 0000-0002-9993-5767

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Highly pathogenic avian influenza (HPAI) A(H5N1) clade 2.3.4.4b virus was identified in 4 cull dairy cows condemned by the U.S. Department of Agriculture because of pneumonia with accompanying systemic changes. Histologic findings were bronchopneumonia in 3 cows and embolic pneumonia and nephritis in 1 cow. In addition to detection of HPAI A(H5N1) virus by reverse-transcription real-time PCR in various formalin-fixed, paraffin-embedded tissues, influenza A virus was detected by immunohistochemistry and in situ hybridization in the pulmonary respiratory epithelium of 2 of the cows with bronchopneumonia and in renal medullary tubules of the cow with nephritis. A PCR panel screening for common bovine respiratory pathogens in the cows with bronchopneumonia revealed variable coinfections with

Indexed as

dairy cowshighly pathogenic avian influenzaHPAI A(H5N1)pneumonia

Identifiers

PMID41685536
PMCPMC12904801

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.