Evidence map›Paper›PMID 41685403›Full record

ArticleJournal of diabetes investigation2026

Continuous glucose monitoring reveals bimodal glycemic patterns during and outside Capivasertib administration.

Yuya Suzuki, Takeshi Yamaguchi, Takayasu Uchida, Kimio Matsumura, Nozomi Harai, Kaoru Nagasawa, Yuko Tanabe, Koichi Suyama, Takashi Kadowaki, Yasumichi Mori

Abstract readCase Reports
In one paragraph

Article in Journal of diabetes investigation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yuya SuzukiDepartment of Endocrinology and Metabolism, Toranomon Hospital, Tokyo, Japan.
Takeshi YamaguchiDepartment of Medical Oncology, Toranomon Hospital, Tokyo, Japan.
Takayasu UchidaDepartment of Endocrinology and Metabolism, Toranomon Hospital, Tokyo, Japan.
Kimio MatsumuraDepartment of Endocrinology and Metabolism, Toranomon Hospital, Tokyo, Japan.
Nozomi HaraiDepartment of Endocrinology and Metabolism, Toranomon Hospital, Tokyo, Japan.ORCID https://orcid.org/0000-0001-5273-4602
Kaoru NagasawaDepartment of Endocrinology and Metabolism, Toranomon Hospital, Tokyo, Japan.
Yuko TanabeDepartment of Medical Oncology, Toranomon Hospital, Tokyo, Japan.ORCID https://orcid.org/0000-0001-9279-5952
Koichi SuyamaDepartment of Medical Oncology, Toranomon Hospital, Tokyo, Japan.
Takashi KadowakiDepartment of Endocrinology and Metabolism, Toranomon Hospital, Tokyo, Japan.
Yasumichi MoriDepartment of Endocrinology and Metabolism, Toranomon Hospital, Tokyo, Japan.ORCID https://orcid.org/0009-0001-3035-0672

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Capivasertib, an AKT inhibitor, interferes with insulin signaling and can induce hyperglycemia. In this case, we monitored blood glucose fluctuations using continuous glucose monitoring (CGM) during capivasertib administration. During the administration period, a post-dose increase in blood glucose was observed, peaking approximately 4 h after oral administration. Additionally, hypoglycemia was detected the following morning, corresponding to approximately 10 h after dinner. These glycemic fluctuations were observed exclusively on dosing days and were completely absent during rest days. The findings highlight the importance of monitoring not only fasting glucose but also post-dose glucose levels for effective glycemic management during capivasertib therapy.

Indexed as

Blood GlucoseHyperglycemiaHypoglycemiaProtein Kinase InhibitorsPyrimidinesPyrrolesContinuous Glucose MonitoringHumansMaleBlood GlucosecapivasertibProtein Kinase InhibitorsPyrimidinesPyrrolesCapivasertibContinuous glucose monitoringHyperglycemia

Identifiers

PMID41685403
PMCPMC13042936

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.