Evidence map›Paper›PMID 41685359›Full record

ArticleNAR molecular medicine2026

Bio-orthogonal chemistry-based strategy to Turn-OFF CRISPR-Cas9 activity in solution and live cells.

Bhoomika Pandit, Sweta Vangaveti, Justa F Sentre, Ian McClain, Gabriele Fuchs, Maksim Royzen

Abstract read
In one paragraph

Article in NAR molecular medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Bhoomika PanditDepartment of Chemistry, University at Albany, 1400 Washington Ave. Albany, NY 12208, United States.
Sweta VangavetiThe RNA Institute, University at Albany, 1400 Washington Ave. Albany, NY 12208, United States.ORCID https://orcid.org/0000-0002-2274-9544
Justa F SentreDepartment of Chemistry, University at Albany, 1400 Washington Ave. Albany, NY 12208, United States.
Ian McClainDepartment of Chemistry, University at Albany, 1400 Washington Ave. Albany, NY 12208, United States.
Gabriele FuchsDepartment of Biology, University at Albany, 1400 Washington Ave. Albany, NY 12208, United States.
Maksim RoyzenDepartment of Chemistry, University at Albany, 1400 Washington Ave. Albany, NY 12208, United States.ORCID https://orcid.org/0000-0002-2930-2171

Funding

Synthesis and non-chromatographic purification of long RNA oligonucleotides containing naturally occurring modificationR21HG012257 · NHGRI · STATE UNIVERSITY OF NEW YORK AT ALBANY · PI ROYZEN, MAKSIM · 2022 to 2024
$620k
NHGRI NIH HHS R21 HG012257
6 · The paper itself

Abstract

The CRISPR-Cas9 system has become a widely used gene-editing tool. Here, we present a new method for small-molecule control of CRISPR-Cas9 using bio-orthogonal chemistry between tetrazine (Tz) and

Identifiers

PMID41685359
PMCPMC12891993

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.