ArticleFrontiers in immunology2026
Extraction, purification, structural elucidation, and immunomodulatory activity of
Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Acid Degradation, Structure Characterization of a Novel Polysaccharide from Leaves ofMolecules (Basel, Switzerland) · 2026Article
- Polysaccharides from the root tubers ofFrontiers in pharmacology · 2026Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Methods: A neutral polysaccharide (BSP-2) was isolated from Results: BSP-2 exhibited the following molecular weight parameters: number-average (3.612 ± 0.13646 kDa), weight-average (4.456 ± 0.18019 kDa), z-average (6.364 ± 0.5518 kDa), and peaked molecular weight (2.808 ± 0.09041 kDa). Component analysis revealed that BSP-2 was dominated by glucose (Glc), with minor proportions of galactose (Gal), arabinose (Ara), and rhamnose (Rha) residues. In LPS-stimulated RAW264.7 cells, BSP-2 inhibited the production of four pro-inflammatory mediators: IFN-γ, TNF-α, IL-1β, and IL-6. Mechanistically, the anti-inflammatory effects of BSP-2 were mediated by the regulation of the NF-κβ pathway, which involved the downregulation of proteins including p65, p-p65, IκBα, p-IκBα, COX-2, and iNOS. Discussion: These results demonstrate that BSP-2 balances pro-inflammatory responses via the NF-κB pathway, supporting its promising application as a bioactive immunoregulatory component in functional food and dietary supplement development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.