ArticleResearch and practice in thrombosis and haemostasis2026
Distinct fibrin clot characteristics in individuals with severe obesity and metabolic liver disease: 2-year follow-up after bariatric surgery.
Article in Research and practice in thrombosis and haemostasis, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Obesity predisposes individuals to metabolic dysfunction-associated steatotic liver disease (MASLD), the hepatic manifestation of metabolic syndrome. Studies in mice suggest that fibrin deposition in adipose tissue and liver promotes obesity and MASLD, but whether similar mechanisms are linked to metabolic disease in humans is incompletely studied. Objectives: This study determined the relationship between plasma fibrin clot characteristics and hepatic fibrin deposition with obesity and MASLD severity and examined changes in fibrin measures 2 years after bariatric surgery. Methods: We included 195 individuals with body mass index (BMI) of > 35 kg/m Results: Examination of plasma clots revealed that individuals with BMI > 45 kg/m Conclusion: Severe obesity and MASLD are associated with altered fibrin characteristics in plasma clots and liver tissue, suggesting fibrin(ogen) reflects metabolic alterations although the directionality remains to be clarified.
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