ArticleAdvances in radiation oncology2026
Myeloablative Total Body Irradiation With Volumetric Modulated Arc Therapy for Children-a Single Center Experience.
Article in Advances in radiation oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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10 authors.
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Abstract
Purpose: Total body irradiation (TBI) is a critical component of conditioning therapy prior to allogeneic hematopoietic stem cell transplantation in pediatric acute lymphoblastic leukemia. Our institution implemented volumetric modulated arc therapy-TBI (VMAT-TBI) in 2023, aiming to improve target conformity and organ-at-risk sparing using standard linear accelerators. This study describes our initial 2-year institutional experience with VMAT-TBI, focusing on treatment planning and delivery metrics, as well as early clinical outcomes and acute toxicities in pediatric patients. Methods and Materials: We conducted a review of 10 pediatric patients treated with VMAT-TBI at our institution from October 2023 to June 2025. All patients received myeloablative conditioning with 12 Gy in 6 fractions over 3 days, followed by intravenous etoposide preceding allogeneic hematopoietic stem cell transplantation. Data collected included treatment planning parameters, planning duration, delivery times, overall survival, relapse-free survival, and acute toxicities. Results: Treatment plans achieved robust target coverage ( Conclusions: Our early institutional experience demonstrates that VMAT-TBI is safe, feasible, and effective in pediatric patients, achieving excellent target coverage and acceptable acute toxicity profiles. These findings support the viability of implementing VMAT-TBI even in resource-constrained settings.
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