Evidence map›Paper›PMID 41685177›Full record

ArticleRespirology case reports2026

Amiodarone-Induced Pneumonia Without Foamy Macrophages in the BALF: A Diagnostic Challenge Unveiled by Cryobiopsy.

Tomo Tsunoda, Kazuo Tsuchiya, Yoshiyuki Oyama, Shusuke Yazawa, Ryota Miyamoto, Taisuke Ito, Takuro Akashi, Noriyuki Enomoto, Tomoyuki Fujisawa, Masaki Ikeda and 1 more

Abstract read
In one paragraph

Article in Respirology case reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Tomo TsunodaDepartment of Respiratory Medicine Shizuoka Saiseikai General Hospital Shizuoka Japan.ORCID https://orcid.org/0009-0006-5450-445X
Kazuo TsuchiyaDepartment of Respiratory Medicine Shizuoka Saiseikai General Hospital Shizuoka Japan.ORCID https://orcid.org/0000-0001-5263-3238
Yoshiyuki OyamaDepartment of Respiratory Medicine Shizuoka Saiseikai General Hospital Shizuoka Japan.ORCID https://orcid.org/0000-0002-4222-5377
Shusuke YazawaSecond Division, Department of Internal Medicine Hamamatsu University School of Medicine Hamamatsu Japan.
Ryota MiyamotoDepartment of Respiratory Medicine Shizuoka Saiseikai General Hospital Shizuoka Japan.
Taisuke ItoDepartment of Respiratory Medicine Shizuoka Saiseikai General Hospital Shizuoka Japan.
Takuro AkashiDepartment of Respiratory Medicine Shizuoka Saiseikai General Hospital Shizuoka Japan.
Noriyuki EnomotoSecond Division, Department of Internal Medicine Hamamatsu University School of Medicine Hamamatsu Japan.ORCID https://orcid.org/0000-0003-3187-4264
Tomoyuki FujisawaSecond Division, Department of Internal Medicine Hamamatsu University School of Medicine Hamamatsu Japan.ORCID https://orcid.org/0000-0002-8809-1781
Masaki IkedaDepartment of Respiratory Medicine Shizuoka Saiseikai General Hospital Shizuoka Japan.
Takafumi SudaSecond Division, Department of Internal Medicine Hamamatsu University School of Medicine Hamamatsu Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A 64-year-old man with a mild cough presented with abnormal chest imaging with centrilobular ground-glass opacities in the upper lobes, peribronchovascular and subpleural consolidation and small nodules. Bronchoalveolar lavage fluid (BALF) lacked foamy macrophages, transbronchial lung cryobiopsy revealed features consistent with amiodarone-induced interstitial pneumonia, including vacuolization of type II alveolar epithelial cells, lymphoid follicle formation and granulation tissue. After discontinuation of amiodarone, the patient's symptoms and radiographic abnormalities improved. This case highlights that the absence of foamy macrophages in BALF should not preclude amiodarone-induced pneumonia, and that histological evaluation plays a pivotal role in establishing an accurate diagnosis.

Indexed as

amiodarone‐induced pneumoniabroncho‐alveolar lavage fluidfoamy macrophagetransbronchial lung cryobiopsy

Identifiers

PMID41685177
PMCPMC12891811

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.