ReviewMetabolism open2026
Gene and non-coding RNA expression in human cumulus cells in polycystic ovary syndrome: A systematic review.
Review in Metabolism open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
0 citing papers in PubMed.
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Corrections and comments
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: This systematic review aimed to synthesize and critically appraise human studies on coding and non-coding RNA expression in cumulus cells (CCs) from women with Polycystic Ovary Syndrome (PCOS), to map consistently dysregulated pathways, evaluate links to oocyte competence, and identify key methodological limitations. Methods: A systematic search of five electronic databases (MEDLINE/PubMed, Embase, Web of Science, Scopus, Cochrane CENTRAL) was conducted from inception to October 25, 2025. Peer-reviewed human studies comparing CC RNA expression in PCOS versus controls, with explicit cumulus isolation and primary RNA data, were included. Study selection, quality assessment, and data extraction followed pre-defined analytic prisms focusing on cell-type specificity, oocyte maturation stage, stimulation protocol, and clinical phenotype. A qualitative synthesis was performed due to substantial clinical and methodological heterogeneity. Results: Thirty-three studies were included. The CC transcriptome in PCOS is characterized by a coherent phenotype: pathway-level enrichment of EGFR-MAPK and PI3K-AKT/insulin signaling, an imbalanced TGF-β/oocyte-somatic cell axis, and blunted induction of cumulus expansion/extracellular matrix (ECM) genes (e.g., TNFAIP6, PTX3). Non-coding RNA profiles (miRNAs, lncRNAs, circRNAs) corroborate these findings, targeting the same pathways. These signatures are strongly modified by oocyte maturation stage (largest differences at Germinal Vesicle stage), stimulation protocols, and clinical phenotypes (e.g., insulin resistance, obesity). Conclusion: The cumulus cell phenotype in PCOS reflects a rewired signaling environment that converges on defective matrix assembly, providing a molecular framework for impaired oocyte competence. Future research requires stage-aware, phenotype-stratified designs with standardized reporting to translate these findings into robust biomarkers for assisted reproduction.
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Registered trials
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