ReviewNational science review2026
Wakefulness regulation of memory encoding and retrieval: structure and activity.
Review in National science review, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
6 authors.
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Abstract
Sleep-wake states are fundamental regulators of memory processing. While memory consolidation relies on sleep, memory encoding and retrieval depend primarily on wakefulness. Although the role of sleep in memory consolidation has been extensively characterized, the contribution of wakefulness to memory encoding and retrieval remains less systematically summarized. In this review, we synthesize current evidence on how wakefulness regulates memory through two key dimensions: (i) structural organization, defined by the anatomical innervation of memory-related brain regions by the wakefulness system; and (ii) activity-dependent regulation, in which arousal states modulate the efficiency of memory encoding and retrieval. We highlight three major mechanisms-memory engrams, synaptic plasticity and neural oscillations-and propose adult hippocampal neurogenesis (AHN) as an additional timescale-specific mechanism linking wakefulness to memory. Finally, we discuss how wakefulness abnormalities disrupt memory encoding and retrieval in aging, Alzheimer's disease and post-general anesthesia, and suggest that moderate enhancement of arousal level provides a novel strategy for improving memory function.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.