Evidence map›Paper›PMID 41685090›Full record

ArticleFrontiers in cellular neuroscience2025

Neuronal activity drives PCDH9 cleavage and nuclear translocation to coordinate structural and functional remodeling.

Federico Miozzo, Annalaura Zambrano Avendano, Maria Giuseppa Caso, Benedetta Valentino, Shinji Hirano, Luca Murru, Edoardo Moretto, Maria Passafaro

Abstract read
In one paragraph

Article in Frontiers in cellular neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Federico MiozzoInstitute of Neuroscience, CNR, Vedano Al Lambro, Italy.
Annalaura Zambrano AvendanoInstitute of Neuroscience, CNR, Vedano Al Lambro, Italy.
Maria Giuseppa CasoInstitute of Neuroscience, CNR, Vedano Al Lambro, Italy.
Benedetta ValentinoInstitute of Neuroscience, CNR, Vedano Al Lambro, Italy.
Shinji HiranoLaboratory of Cell Biology, Faculty of Medicine, Kansai Medical University, Hirakata, Osaka, Japan.
Luca MurruInstitute of Neuroscience, CNR, Vedano Al Lambro, Italy.
Edoardo MorettoInstitute of Neuroscience, CNR, Vedano Al Lambro, Italy.
Maria PassafaroInstitute of Neuroscience, CNR, Vedano Al Lambro, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Protocadherins are key regulators of neurodevelopment and synaptic function, acting not only as adhesion molecules but also as synaptic hubs for intracellular signaling. Here, we uncover a novel activity-dependent signaling pathway for

Indexed as

activity-dependent signalingcleavagematrix metalloproteasesplasticityProtocadherin 9regulated intramembrane proteolysissynapse

Identifiers

PMID41685090
PMCPMC12890670

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.