Evidence map›Paper›PMID 41685082›Full record

ArticleBJA open2026

General anaesthesia

Maziar M Nourian, Amelie Delaporte, Theodora Wingert, Nancy M Boulos, Tristan Grogan, Emily Methangkool, Jacques Neelankavil, Louis A Saddic, Maxime Cannesson, Olaf Mercier and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BJA open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Maziar M NourianDepartment of Anaesthesiology & Perioperative Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.
Amelie DelaporteDepartment of Anaesthesiology & Perioperative Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.
Theodora WingertDepartment of Anaesthesiology & Perioperative Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.
Nancy M BoulosDepartment of Anaesthesiology & Perioperative Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.
Tristan GroganDepartment of Medicine Statistics Core, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.
Emily MethangkoolDepartment of Anaesthesiology & Perioperative Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.
Jacques NeelankavilDepartment of Anaesthesiology & Perioperative Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.
Louis A SaddicDepartment of Anaesthesiology & Perioperative Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.
Maxime CannessonDepartment of Anaesthesiology & Perioperative Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.
Olaf MercierDepartment of Thoracic Surgery and Heart-Lung Transplantation, Hôpital Marie Lannelongue, Le Plessis-Robinson, France.
Soban UmarDepartment of Anaesthesiology & Perioperative Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.
Marc HumbertFaculty of Medicine, Paris-Saclay University, Le Kremlin-Bicêtre, France.
Laurent SavaleFaculty of Medicine, Paris-Saclay University, Le Kremlin-Bicêtre, France.
Alexandre JoostenDepartment of Anaesthesiology & Perioperative Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.

Funding

Investigating the molecular mechanisms of right ventricular failure in pulmonary hypertensionR01HL161038 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Soban Umar · 2022 to 2026
$1.9M
NHLBI NIH HHS R01 HL161038
6 · The paper itself

Abstract

Background: Pulmonary hypertension, often indicated before surgery by elevated right ventricular systolic pressure (RVSP) on echocardiography, is associated with increased perioperative risk. For low-risk procedures in which either general anaesthesia or monitored anaesthesia care may be selected, comparative data on postoperative outcomes are limited. Methods: We conducted a single-centre retrospective observational cohort study of 4962 adults with RVSP >50 mm Hg who underwent low-risk procedures. Eligible procedures included endoscopy, bronchoscopy, catheterisation laboratory interventions, and peripheral surgeries. The primary outcome was a composite of acute kidney injury, acute myocardial injury, or 30-day mortality. Analyses used multivariable logistic regression and inverse probability of treatment weighting based on preoperative covariates. Intraoperative variables were evaluated as potential mediators in sensitivity analyses. Results: Of the 4962 patients, 2473 received general anaesthesia and 2489 received monitored anaesthesia care. In preoperative-adjusted models, general anaesthesia was associated with higher odds of major complications (odds ratio, 1.24; 95% confidence interval [95% CI], 1.02-1.51; Conclusions: After adjustment for preoperative risk and evaluating intraoperative mediators, we found no evidence of a statistically significant difference in major postoperative complications between general anaesthesia and monitored anaesthesia care in adults with elevated RVSP undergoing low-risk procedures.

Indexed as

anaesthesiaconscious sedationgeneralhealth careoutcome assessmentperioperative carepostoperative complicationspulmonary hypertensionright ventricular function

Identifiers

PMID41685082
PMCPMC12890821

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.