Large Pleomorphic Adenoma of The Upper Lip in a Middle-Aged Woman With Facial Deformity, Tooth Displacement, and Bone Loss: Uncommon Clinical Presentation of a Benign Tumor.

Pleomorphic adenoma (PA) is the most common benign neoplasm of the salivary glands, occurring in both major and minor glands, with a predilection for the intraoral palate. Its presentation in the upper lip is rare and, when large, may result in facial deformity, alveolar bone resorption, and tooth displacement, especially in long-standing lesions. Clinically, PA presents as a solid, painless, slow-growing, and well-circumscribed mass, which may cause functional morbidity depending on its size and location. The differential diagnosis includes canalicular adenoma, other benign minor salivary gland neoplasms, mesenchymal tumors (lipoma, fibroma, neurofibroma, schwannoma, and hemangioma), and cystic lesions (mucocele, dermoid cyst, and epidermoid cyst). Distinguishing among these entities requires a detailed clinical evaluation, imaging studies, and histopathological confirmation, often complemented by immunohistochemistry. Complete excisional biopsy with adequate margins remains the treatment of choice, providing an excellent prognosis and reducing the risk of recurrence or malignant transformation. This report describes an uncommon case of large PA of the upper lip, associated with alveolar bone loss and tooth displacement, highlighting the importance of early diagnosis and appropriate surgical management.