Evidence map›Paper›PMID 41684937›Full record

ArticlebioRxiv : the preprint server for biology2026

Mapping the Mutational Landscape for Streptokinase Binding to Plasminogen.

Srishti Baid, Matthew L Holding, Taylor Laurin, David Seimeiniak, David Ginsburg, Laura M Haynes

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Srishti BaidLife Sciences Institute, University of Michigan, Ann Arbor.ORCID 0000-0002-8371-3588
Matthew L HoldingLife Sciences Institute, University of Michigan, Ann Arbor.ORCID 0000-0003-3477-3012
Taylor LaurinLife Sciences Institute, University of Michigan, Ann Arbor.ORCID 0009-0003-8596-0317
David SeimeiniakLife Sciences Institute, University of Michigan, Ann Arbor.
David GinsburgLife Sciences Institute, University of Michigan, Ann Arbor.ORCID 0000-0002-6436-8942
Laura M HaynesLife Sciences Institute, University of Michigan, Ann Arbor.ORCID 0000-0002-2237-659X

Funding

The Molecular Genetics of HemostasisR35HL171421 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI David Ginsburg · 2024 to 2026
$2.8M
NHLBI NIH HHS R35 HL171421
6 · The paper itself

Abstract

Group A Streptococcus (GAS) expresses streptokinase (SK), a critical virulence factor that non-enzymatically activates the host's plasminogen (PLG), to an active form, PLG

Indexed as

deep mutational scanningGroup A Streptococcushost-pathogen interactionstreptokinase

Identifiers

PMID41684937
PMCPMC12893055

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.