Evidence map›Paper›PMID 41684844›Full record

ArticleiScience2026

Prelimbic cortex-basolateral amygdala glutamatergic circuit drives cancer-induced bone pain in mice.

Qi-Yan Feng, Jin-Rong Wei, Meng-Xue Song, Zi-Yue Deng, Yong-Chang Li, Shu-Fen Hu, Fu-Chao Zhang, Hai-Long Zhang, Guang-Yin Xu, Guo-Qin Jiang

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In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Qi-Yan FengDepartment of General Surgery, The Second Affiliated Hospital of Soochow University, Suzhou 215004, China.
Jin-Rong WeiDepartment of General Surgery, The Second Affiliated Hospital of Soochow University, Suzhou 215004, China.
Meng-Xue SongDepartment of General Surgery, The Second Affiliated Hospital of Soochow University, Suzhou 215004, China.
Zi-Yue DengJiangsu Key Laboratory of Neuropsychiatric Diseases and Institute of Neuroscience, Soochow University, Suzhou 215123, P.R. China.
Yong-Chang LiJiangsu Key Laboratory of Neuropsychiatric Diseases and Institute of Neuroscience, Soochow University, Suzhou 215123, P.R. China.
Shu-Fen HuJiangsu Key Laboratory of Neuropsychiatric Diseases and Institute of Neuroscience, Soochow University, Suzhou 215123, P.R. China.
Fu-Chao ZhangJiangsu Key Laboratory of Neuropsychiatric Diseases and Institute of Neuroscience, Soochow University, Suzhou 215123, P.R. China.
Hai-Long ZhangCenter of Translational Medicine and Clinical Laboratory, The Fourth Affiliated Hospital of Soochow University, Suzhou 215123, China.
Guang-Yin XuJiangsu Key Laboratory of Neuropsychiatric Diseases and Institute of Neuroscience, Soochow University, Suzhou 215123, P.R. China.
Guo-Qin JiangDepartment of General Surgery, The Second Affiliated Hospital of Soochow University, Suzhou 215004, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cancer-induced bone pain (CIBP), resulting from bone metastases, is excruciating and lacks effective treatment. Previous studies on CIBP mechanisms mainly focused on the peripheral nervous system and spinal cord, with limited attention to the brain. This study investigates the prelimbic cortex (PrL) to basolateral amygdala (BLA) circuit in regulating CIBP in female mice. CIBP models were established by injecting E0771 cells into the tibias of C57BL/6J female mice. c-Fos expression and calcium activity in BLA

Indexed as

Biological sciencesCancerNeuroscience

Identifiers

PMID41684844
PMCPMC12890714

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.