ReviewFrontiers in cell and developmental biology2026
Metabolic reprogramming and immunosenescence: a new sight for glioma therapy.
Review in Frontiers in cell and developmental biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Identification of a lncRNA prognostic signature reveals that SNAI3-AS1 cooperates with erastin to reshape macrophage polarization in glioma.Medical oncology (Northwood, London, England) · 2026Article
- Metabolic Reprogramming and Neurotransmitter Signaling Co-Option in the Glioma Immune Microenvironment: Dual-Axis Regulation of Immunosuppression.Biomolecules · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gliomas, the most prevalent primary tumor of the central nervous system, are characterized by a poor prognosis and a high recurrence rate. The glioma microenvironment is highly immunosuppressive, which poses a major obstacle to effective immunotherapy. Metabolic reprogramming is a hallmark of glioma, driving tumor progression and therapy resistance. Key alterations include the Warburg effect, increased glutamine dependency, enhanced pentose phosphate pathway activity, and dysregulated lipid metabolism. Immunosenescence, the age-dependent decline in immune function that contributes to disease pathogenesis, encompasses immune dysregulation, senescence-associated secretory phenotype (SASP) accumulation, and epigenetic changes, which together drive immune cell dysfunction and foster an immunosuppressive microenvironment. Meantime, senescent immune cells may change the metabolic microenvironment, whereas metabolic reprogramming also influence immune system. Thus, this small essay is on the purpose of demonstrating the significance and function of metabolic reprogramming and immunosenescence in gliomas, providing evidence of promising therapeutic strategies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.