Evidence map›Paper›PMID 41684752›Full record

ArticleResearch square2026

Transplantation of Human IPSC-derived Microglia Ameliorates Neuropathology and Circuit Dysfunction in Progranulin-Deficient Mice.

Hayk Davtyan, Sarah Naguib, Yuliya Voskobiynyk, Jean Paul Chadarevian, Joia K Capocchi, Jeannie L Giacchino, Ghazaleh Eskandari-Sedighi, Vivianna DeNittis, Jeremy B Ford, Ani Agababian and 17 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in Research square, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

27 authors.

Hayk DavtyanUniversity of California, Irvine.
Sarah NaguibWeill Cornell Medicine.
Yuliya VoskobiynykGladstone Institutes.
Jean Paul ChadarevianUniversity of California, Irvine.
Joia K CapocchiUniversity of California, Irvine.
Jeannie L GiacchinoGladstone Institutes.
Ghazaleh Eskandari-SedighiUniversity of California, Irvine.
Vivianna DeNittisGladstone Institutes.
Jeremy B FordGladstone Institutes.
Ani AgababianUniversity of California, Irvine.
Jasmine NguyenUniversity of California, Irvine.
Alina L ChadarevianUniversity of California, Irvine.
Madison S SutherlandUniversity of California, Irvine.
Sepideh Kiani ShabestariUniversity of California, Irvine.
Alissa L NanaUniversity of California, Irvine.
Jiasheng ZhangWashington University in St. Louis.
Salvatore SpinaUniversity of California, San Francisco.
Man Ying WongWeill Cornell Medicine.
Lea T GrinbergUniversity of California, San Francisco.
William W SeeleyUniversity of California, San Francisco.
Eric HuangWashington University in St. Louis.
Claire D ClellandUniversity of California, San Francisco.
Shiaoching GongWeill Cornell Medicine.
Li FanWeill Cornell Medicine.
Jeanne T PazGladstone Institutes.
Mathew Blurton-JonesUniversity of California, Irvine.
Li GanWeill Cornell Medicine.

Funding

Training in the Neurobiology of Aging and Alzheimers DiseaseT32AG000096 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI VIVEK SWARUP, Craig E Stark · 1985 to 2026
$9.6M
Using human iPSC derived microglia and chimeric models to examine the role of PLCG2 in Alzheimers diseaseR01AG061895 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI DAVTYAN, HAYK · 2018 to 2022
$2.9M
Examining the role of adaptive immunity in Alzheimer's Disease pathogenesisRF1AG055524 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI BLURTON-JONES, MATHEW MARK · 2017 to 2017
$2.7M
Training in Translational ADRD Neuroscience (TITAN)T32AG073088 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI Joshua Grill, Elizabeth Head · 2021 to 2026
$2.2M
Role of Myeloid And CD4+ T Immune Cells in Post-Traumatic PlasticityR01NS121287 · NINDS · J. DAVID GLADSTONE INSTITUTES · PI Jeanne T Paz · 2022 to 2026
$2.2M
Manipulating DNA repair enzymes to examine the interactions between aging and Alzheimers disease with iPSC-derived microgliaR01AG056303 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI BLURTON-JONES, MATHEW MARK · 2017 to 2021
$1.9M
The role of TREM2 in human microglial function and Alzheimer disease pathogenesisRF1AG048099 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI BLURTON-JONES, MATHEW MARK · 2014 to 2014
$1.9M
NIA NIH HHS R01 AG056303NIA NIH HHS R01 AG061895NIA NIH HHS RF1 AG048099NIA NIH HHS RF1 AG055524NIA NIH HHS T32 AG000096NIA NIH HHS T32 AG073088NINDS NIH HHS R01 NS121287
6 · The paper itself

Abstract

Frontotemporal dementia (FTD) is a major cause of early-onset neurodegeneration characterized by progressive behavioral, emotional, and cognitive decline. Progranulin haploinsufficiency, a leading genetic cause of familial FTD, disrupts lysosomal function, lipid metabolism, autophagy, and neuroimmune signaling across multiple cell types. Increasing evidence indicates that microglia are particularly sensitive to progranulin loss, exhibiting elevated complement activation that contributes to TDP-43 proteinopathy and neuronal dysfunction. Here, we investigate the biological role of restoring progranulin exclusively within microglia by transplanting human induced pluripotent stem cell-derived microglia (iMG) into progranulin (

Identifiers

PMID41684752
PMCPMC12893066

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.