Evidence map›Paper›PMID 41684747›Full record

ArticleSynthetic and systems biotechnology2026

A novel TetR-type repressor directly modulates precursor supply and utilization for erythromycin biosynthesis.

Panpan Wu, Zhongqiu Meng, Yuling Shu, Ketao Chen, Zhenyue Xu, Xunduan Huang, Buchang Zhang, Jing Liu, Hang Wu

Abstract read
In one paragraph

Article in Synthetic and systems biotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Panpan WuSchool of Life Sciences and Medical Engineering, Anhui University, Hefei, 230601, China.
Zhongqiu MengSchool of Life Sciences and Medical Engineering, Anhui University, Hefei, 230601, China.
Yuling ShuSchool of Life Sciences and Medical Engineering, Anhui University, Hefei, 230601, China.
Ketao ChenSchool of Life Sciences and Medical Engineering, Anhui University, Hefei, 230601, China.
Zhenyue XuSchool of Life Sciences and Medical Engineering, Anhui University, Hefei, 230601, China.
Xunduan HuangSchool of Life Sciences and Medical Engineering, Anhui University, Hefei, 230601, China.
Buchang ZhangSchool of Life Sciences and Medical Engineering, Anhui University, Hefei, 230601, China.
Jing LiuSchool of Life Sciences, Anhui Agricultural University, Hefei, 230036, China.
Hang WuSchool of Life Sciences and Medical Engineering, Anhui University, Hefei, 230601, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Antibiotic biosynthesis in actinomycetes is controlled by various transcription factors, with TetR family regulators (TFRs) serving as important modulators of this process. We previously discovered a TFR, SACE_1906, which hinders erythromycin yield in

Indexed as

Biosynthetic precursorEffectorErythromycinSaccharopolyspora erythraeaTetR family regulator

Identifiers

PMID41684747
PMCPMC12890868

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.