ArticleArchives of medical science : AMS2025
Preoperative calcium and vitamin D supplementation may reduce postoperative hypocalcaemia after total thyroidectomy.
Article in Archives of medical science : AMS, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Hypocalcaemia is the most common postoperative complication after total thyroidectomy. The purpose of the study was to evaluate the clinical usefulness of routine preoperative oral calcium and vitamin D supplementation in the prevention of hypocalcaemia after total thyroidectomy. Material and methods: One hundred and fifty-three consecutive patients with nontoxic multinodular goitre were randomly assigned to routinely receive (group B) or not receive (group A) calcium carbonate (3 g/day) and alfacalcidol (1 µg/day) on the day before surgery and calcium carbonate (1 g/day) and alfacalcidol (1 µg/day) taken once in the morning on the day of the operation. Their preoperative 25-hydroxyvitamin D (25-OHD) levels, hypocalcaemic symptoms, serum calcium and parathyroid hormone (iPTH) levels were determined 6 and 24 h and 6 weeks after surgery. Results: Symptomatic hypocalcaemia was observed in 41/153 (26.79%) patients. The incidence of symptomatic hypocalcaemia was significantly lower in the supplemented group than in the group not receiving supplementation: 10 of 77 participants (12.99%) versus 31 of 76 patients (40.79%) ( Conclusions: Oral supplementation with calcium and alfacalcidol may reduce post-thyroidectomy hypocalcaemia. Vitamin D deficiency was common among the study population.
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