ArticleArchives of medical science : AMS2025
Myrcene enhances the cardioprotective effect through matrix remodelling in an experimental model of heart failure.
Article in Archives of medical science : AMS, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Chemical Constituents of the Essential Oil from Ecuadorian Endemic SpeciesMolecules (Basel, Switzerland) · 2021Article
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Authors and funding
7 authors.
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Abstract
Introduction: Myrcene, a terpene found in essential oils sourced from plants, is known to elicit various biological effects such as antioxidant, anti-inflammatory, hypoglycaemic, and hepatoprotective activities. However, reports on the protective effect of myrcene against heart failure are still not clear. Hence, in the present study, the experimental model of heart failure was induced using isoproterenol in rats. Material and methods: Wistar male rats were divided into four groups: group I - Control; group II - ISO-induced heart failure; group III - Myrcene pre-treated (1.0 mg/kg/day and ISO); and group IV - Myrcene drug control for the experimental period of 4 weeks. At the end of the treatment, infarct size, cardiac markers, cell stress enzymes such as creatinine kinase, lactate dehydrogenase, inflammatory markers, matrix proteins, and microRNA signatures were elucidated using RT-PCR, ELISA, and immunohistochemistry analysis. Results: Rats with induced heart failure demonstrated abnormality in cardiac functions and marker gene expressions, while myrcene pre-treated rats prevented cardiac failure significantly ( Conclusions: Myrcene protected hearts from ISO-induced failure in rats and provided a cardioprotective effect via restoring the matrix signalling, anti-inflammatory, and antioxidant effect, which suggests a possible drug candidature for the treatment of cardiac failure.
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