Evidence map›Paper›PMID 41684538›Full record

ArticleFrontiers in immunology2025

Inactivation of cofilin-1 in Mcpt5-Cre-nf-Cfl1

Johanna Kramer, Jakob Schneider, Huiying Liu, Cinthia Silva-Vilches, Sonja Moos, Nadine Kamenjarin, Katrin Hodapp, Volodymyr Tsvilovskyy, Marc Freichel, Hans Christian Probst and 3 more

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In one paragraph

Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Johanna KramerSection Molecular Immunology, Institute of Immunology, Heidelberg University Hospital, Heidelberg, Germany.
Jakob SchneiderSection Molecular Immunology, Institute of Immunology, Heidelberg University Hospital, Heidelberg, Germany.
Huiying LiuSection Molecular Immunology, Institute of Immunology, Heidelberg University Hospital, Heidelberg, Germany.
Cinthia Silva-VilchesDepartment of Dermatology, Heidelberg University Hospital, Heidelberg, Germany.
Sonja MoosDepartment of Dermatology, Heidelberg University Hospital, Heidelberg, Germany.
Nadine KamenjarinInstitute for Immunology, University Medical Center Mainz, Mainz, Germany.
Katrin HodappInstitute for Immunology, University Medical Center Mainz, Mainz, Germany.
Volodymyr TsvilovskyyInstitute of Pharmacology, Heidelberg University, Heidelberg, Germany.
Marc FreichelInstitute of Pharmacology, Heidelberg University, Heidelberg, Germany.
Hans Christian ProbstInstitute for Immunology, University Medical Center Mainz, Mainz, Germany.
Karsten MahnkeDepartment of Dermatology, Heidelberg University Hospital, Heidelberg, Germany.
Florian C KurschusDepartment of Dermatology, Heidelberg University Hospital, Heidelberg, Germany.
Yvonne SamstagSection Molecular Immunology, Institute of Immunology, Heidelberg University Hospital, Heidelberg, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Actin-binding proteins play a critical role in regulating the dynamic rearrangement of the actin cytoskeleton, which is essential for maintaining cellular homeostasis and facilitating various processes in eukaryotic cells. Cofilin-1 (Cfl1), an actin-binding protein, promotes the severing and depolymerization of actin filaments. To investigate the function of Cfl1 in mast cells, we generated Mcpt5-Cre-nf-Cfl1

Indexed as

BasophilsCofilin 1Connective Tissue CellsMast CellsAnimalsDisease Models, AnimalGene Knock-In TechniquesMiceMice, TransgenicCofilin 1actin cytoskeleton dynamicsanaphylaxisbasophilsCofilin-1connective tissue mast cells (CTMCs)mast cell-deficient mouse modelMcpt5-Creskin inflammation

Identifiers

PMID41684538
PMCPMC12891179

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.