Evidence map›Paper›PMID 41684518›Full record

ArticleFrontiers in pharmacology2025

Therapeutic effects of

Hoda A Salem, Nermin I Rizk, Moustafa H AbdelSalam, Rehab Ahmed, Hebatallah Husseini Atteia, Ahmed M E Hamdan, Areej A Alghamdi, Manar A Alghusn, Renad A Alatawi, Rawan A Atallah and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Hoda A SalemDepartment of Pharmacy Practice, Faculty of Pharmacy, University of Tabuk, Tabuk, Saudi Arabia.
Nermin I RizkDepartment of Physiology, Faculty of Medicine, University of Tabuk, Tabuk, Saudi Arabia.
Moustafa H AbdelSalamDepartment of Physiology, Faculty of Medicine, University of Tabuk, Tabuk, Saudi Arabia.
Rehab AhmedNatural Products and Alternative Medicine Department, Division of Microbiology, Immunology and Biotechnology, Faculty of Pharmacy, University of Tabuk, Tabuk, Saudi Arabia.
Hebatallah Husseini AtteiaDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Tabuk, Tabuk, Saudi Arabia.
Ahmed M E HamdanDepartment of Pharmacy Practice, Faculty of Pharmacy, University of Tabuk, Tabuk, Saudi Arabia.
Areej A AlghamdiFaculty of Pharmacy, University of Tabuk, Tabuk, Saudi Arabia.
Manar A AlghusnFaculty of Pharmacy, University of Tabuk, Tabuk, Saudi Arabia.
Renad A AlatawiFaculty of Pharmacy, University of Tabuk, Tabuk, Saudi Arabia.
Rawan A AtallahFaculty of Pharmacy, University of Tabuk, Tabuk, Saudi Arabia.
Maryam M AlfuhaymaniFaculty of Pharmacy, University of Tabuk, Tabuk, Saudi Arabia.
Hatun A AlqahtaniFaculty of Pharmacy, University of Tabuk, Tabuk, Saudi Arabia.
Karema Abu-ElfotuhDepartment of Clinical Pharmacy, Faculty of Pharmacy, Al-Azhar University, Cairo, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Autism spectrum disorder (ASD) is a neurodevelopmental disease characterized by repetitive behaviors and a lack of social communication. The role of probiotics, phytochemicals and their combination phytochemicals as treatment options for ASD is still under study. Objective: This study aimed to evaluate the associated molecular pathways and explore the impact of Methods: Fifty 3-week-old male albino rat pups were randomly distributed into five groups. The groups included a control group, a PA-induced ASD group, in which PA (250 mg/kg, p.o.) was administered for 3 days, and three other groups that received PA (250 mg/kg, p.o.) for 3 days along with either Results: Compared with the group administered only PA, treatment with Conclusion: Our results suggest that

Indexed as

autismautophagyendoplasmic reticulum stressoxidative stressprobioticsthymol

Identifiers

PMID41684518
PMCPMC12891102

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.