Evidence map›Paper›PMID 41684497›Full record

ArticleJournal of medical physics

Comparison of Intrafraction Variation of Dose-volume Parameters in Hybrid Brachytherapy for Carcinoma Cervix.

Devender Reddy Boja, Harjot Kaur Bajwa, N V N Madhusudhana Sresty, Deleepkumar Gudipudi, Rohith Singareddy, Hima Bindu Pitta

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Article in Journal of medical physics. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

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6 authors.

Devender Reddy BojaDepartment of Radiation Oncology, Basavatarakam Indo American Cancer Hospital and Research Institute, Hyderabad, Telangana, India.
Harjot Kaur BajwaDepartment of Radiation Oncology, American Oncology of Institute, Hyderabad, Telangana, India.
N V N Madhusudhana SrestyDepartment of Radiation Oncology, Basavatarakam Indo American Cancer Hospital and Research Institute, Hyderabad, Telangana, India.
Deleepkumar GudipudiDepartment of Radiation Oncology, Basavatarakam Indo American Cancer Hospital and Research Institute, Hyderabad, Telangana, India.
Rohith SingareddyDepartment of Radiation Oncology, Basavatarakam Indo American Cancer Hospital and Research Institute, Hyderabad, Telangana, India.
Hima Bindu PittaDepartment of Physics, University College of Science, Osmania University, Hyderabad, Telangana, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: The present study aimed to compare the dosimetric parameters for a fractional re-imaging approach using computed tomographic (CT) scans before the first and third fractions with hybrid brachytherapy for carcinoma cervix patients. Materials and Methods: Patients with cervical carcinoma who received radical chemoradiation and hybrid brachytherapy were prospectively included for the analysis. The first fraction was delivered on day 1 after applicator insertion and the second and third fractions were delivered on day 2, 6 h apart. Two plans were created for each patient using CT-based planning, one before the first fraction (Plan 1) and the other before the third fraction (Plan 2). The dose prescribed was 7 Gy per fraction to high-risk clinical target volume (HRCTV). The dosimetric parameters compared between the two plans were D90 HRCTV, D98 IRCTV, TRAK, D0.1cc, and D2cc to the bladder, rectum, sigmoid, and dose to the ICRU 89 radiation therapy (RV) point, respectively. Results: Fifteen patients were included for the analysis. The mean HRCTV volume was 31 cc. The mean D90 HRCTV was 87.86 Gy EQD2 for Plan 1 versus 84.64 Gy EQD2 for Plan 2, respectively ( Conclusion: In carcinoma cervix patients undergoing hybrid brachytherapy in a single application multiple fraction approach, there can be significant variations in rectum doses. These results indicate that fractional re-imaging is necessary to optimize the plan and spare organ-at-risk.

Indexed as

Carcinoma cervixhybrid intracavitary/interstitial brachytherapyorgan-at-risk

Identifiers

PMID41684497
PMCPMC12893354

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.