ArticleEuropean journal of anaesthesiology and intensive care2026
Clinical implications and feasibility of cerebral autoregulation-based precision blood pressure monitoring in major noncardiac surgery: A protocol for AUTOREGULATE-NONCARDIAC, a multicentre prospective cohort study and peri-operative precision medicine platform.
Registry-linked trialAbstract read
In one paragraph
Article in European journal of anaesthesiology and intensive care, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05336864 (Association of Intraoperative Blood Pressure Excursions Below Cerebral Autoregulatory Boundaries With Organ Injury Following Major Noncardiac Surgery), which is not on this map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Association of Intraoperative Blood Pressure Excursions Below Cerebral Autoregulatory Boundaries With Organ Injury Following Major Noncardiac Surgery (AUTOREGULATE-NONCARDIAC)
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
19 authors.
Patrick M WannerFrom the Anaesthesiology, University Hospital Basel, Basel, Switzerland (PMW, AJMW, ES, ND, LAS), Department of Clinical Research, University of Basel, Basel, Switzerland (PMW, AJMW, LAS), Swiss Tropical and Public Health Institute, Basel, Switzerland (CS), Brain Physics Laboratory, Division of Neurosurgery, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK (EB, PS), Department of Anesthesiology, Bluhm Cardiovascular Institute, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA (CWH), Department of Anesthesiology, Perioperative, and Pain Medicine; Division of Cardiac Anesthesia; Stanford University, Stanford, California, USA (CHB), Department of Anaesthesiology and Pain Medicine, Seoul National University, College of Medicine, Seoul, South Korea (YJ), Department of Cardiology and Cardiovascular Research Institute Basel, University Hospital Basel, Basel, Switzerland (CP), Department of Anaesthesiology, Rescue and Pain Medicine, HOCH Health Ostschweiz St. Gallen, St. Gallen, Switzerland (TY), Centre for Laboratory Medicine, St. Gallen, Switzerland (JB, WK), Division of Peri-operative Intensive Care Medicine, HOCH Health Ostschweiz St. Gallen, St. Gallen, Switzerland (CK, UP, MF), Department of Anaesthesiology and Pain Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland (APV).
Christian SchindlerFrom the Anaesthesiology, University Hospital Basel, Basel, Switzerland (PMW, AJMW, ES, ND, LAS), Department of Clinical Research, University of Basel, Basel, Switzerland (PMW, AJMW, LAS), Swiss Tropical and Public Health Institute, Basel, Switzerland (CS), Brain Physics Laboratory, Division of Neurosurgery, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK (EB, PS), Department of Anesthesiology, Bluhm Cardiovascular Institute, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA (CWH), Department of Anesthesiology, Perioperative, and Pain Medicine; Division of Cardiac Anesthesia; Stanford University, Stanford, California, USA (CHB), Department of Anaesthesiology and Pain Medicine, Seoul National University, College of Medicine, Seoul, South Korea (YJ), Department of Cardiology and Cardiovascular Research Institute Basel, University Hospital Basel, Basel, Switzerland (CP), Department of Anaesthesiology, Rescue and Pain Medicine, HOCH Health Ostschweiz St. Gallen, St. Gallen, Switzerland (TY), Centre for Laboratory Medicine, St. Gallen, Switzerland (JB, WK), Division of Peri-operative Intensive Care Medicine, HOCH Health Ostschweiz St. Gallen, St. Gallen, Switzerland (CK, UP, MF), Department of Anaesthesiology and Pain Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland (APV).
Erta BeqiriFrom the Anaesthesiology, University Hospital Basel, Basel, Switzerland (PMW, AJMW, ES, ND, LAS), Department of Clinical Research, University of Basel, Basel, Switzerland (PMW, AJMW, LAS), Swiss Tropical and Public Health Institute, Basel, Switzerland (CS), Brain Physics Laboratory, Division of Neurosurgery, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK (EB, PS), Department of Anesthesiology, Bluhm Cardiovascular Institute, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA (CWH), Department of Anesthesiology, Perioperative, and Pain Medicine; Division of Cardiac Anesthesia; Stanford University, Stanford, California, USA (CHB), Department of Anaesthesiology and Pain Medicine, Seoul National University, College of Medicine, Seoul, South Korea (YJ), Department of Cardiology and Cardiovascular Research Institute Basel, University Hospital Basel, Basel, Switzerland (CP), Department of Anaesthesiology, Rescue and Pain Medicine, HOCH Health Ostschweiz St. Gallen, St. Gallen, Switzerland (TY), Centre for Laboratory Medicine, St. Gallen, Switzerland (JB, WK), Division of Peri-operative Intensive Care Medicine, HOCH Health Ostschweiz St. Gallen, St. Gallen, Switzerland (CK, UP, MF), Department of Anaesthesiology and Pain Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland (APV).
Peter SmielewskiFrom the Anaesthesiology, University Hospital Basel, Basel, Switzerland (PMW, AJMW, ES, ND, LAS), Department of Clinical Research, University of Basel, Basel, Switzerland (PMW, AJMW, LAS), Swiss Tropical and Public Health Institute, Basel, Switzerland (CS), Brain Physics Laboratory, Division of Neurosurgery, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK (EB, PS), Department of Anesthesiology, Bluhm Cardiovascular Institute, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA (CWH), Department of Anesthesiology, Perioperative, and Pain Medicine; Division of Cardiac Anesthesia; Stanford University, Stanford, California, USA (CHB), Department of Anaesthesiology and Pain Medicine, Seoul National University, College of Medicine, Seoul, South Korea (YJ), Department of Cardiology and Cardiovascular Research Institute Basel, University Hospital Basel, Basel, Switzerland (CP), Department of Anaesthesiology, Rescue and Pain Medicine, HOCH Health Ostschweiz St. Gallen, St. Gallen, Switzerland (TY), Centre for Laboratory Medicine, St. Gallen, Switzerland (JB, WK), Division of Peri-operative Intensive Care Medicine, HOCH Health Ostschweiz St. Gallen, St. Gallen, Switzerland (CK, UP, MF), Department of Anaesthesiology and Pain Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland (APV).
Charles W HogueFrom the Anaesthesiology, University Hospital Basel, Basel, Switzerland (PMW, AJMW, ES, ND, LAS), Department of Clinical Research, University of Basel, Basel, Switzerland (PMW, AJMW, LAS), Swiss Tropical and Public Health Institute, Basel, Switzerland (CS), Brain Physics Laboratory, Division of Neurosurgery, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK (EB, PS), Department of Anesthesiology, Bluhm Cardiovascular Institute, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA (CWH), Department of Anesthesiology, Perioperative, and Pain Medicine; Division of Cardiac Anesthesia; Stanford University, Stanford, California, USA (CHB), Department of Anaesthesiology and Pain Medicine, Seoul National University, College of Medicine, Seoul, South Korea (YJ), Department of Cardiology and Cardiovascular Research Institute Basel, University Hospital Basel, Basel, Switzerland (CP), Department of Anaesthesiology, Rescue and Pain Medicine, HOCH Health Ostschweiz St. Gallen, St. Gallen, Switzerland (TY), Centre for Laboratory Medicine, St. Gallen, Switzerland (JB, WK), Division of Peri-operative Intensive Care Medicine, HOCH Health Ostschweiz St. Gallen, St. Gallen, Switzerland (CK, UP, MF), Department of Anaesthesiology and Pain Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland (APV).
Charles H BrownFrom the Anaesthesiology, University Hospital Basel, Basel, Switzerland (PMW, AJMW, ES, ND, LAS), Department of Clinical Research, University of Basel, Basel, Switzerland (PMW, AJMW, LAS), Swiss Tropical and Public Health Institute, Basel, Switzerland (CS), Brain Physics Laboratory, Division of Neurosurgery, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK (EB, PS), Department of Anesthesiology, Bluhm Cardiovascular Institute, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA (CWH), Department of Anesthesiology, Perioperative, and Pain Medicine; Division of Cardiac Anesthesia; Stanford University, Stanford, California, USA (CHB), Department of Anaesthesiology and Pain Medicine, Seoul National University, College of Medicine, Seoul, South Korea (YJ), Department of Cardiology and Cardiovascular Research Institute Basel, University Hospital Basel, Basel, Switzerland (CP), Department of Anaesthesiology, Rescue and Pain Medicine, HOCH Health Ostschweiz St. Gallen, St. Gallen, Switzerland (TY), Centre for Laboratory Medicine, St. Gallen, Switzerland (JB, WK), Division of Peri-operative Intensive Care Medicine, HOCH Health Ostschweiz St. Gallen, St. Gallen, Switzerland (CK, UP, MF), Department of Anaesthesiology and Pain Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland (APV).
Yunseok JeonFrom the Anaesthesiology, University Hospital Basel, Basel, Switzerland (PMW, AJMW, ES, ND, LAS), Department of Clinical Research, University of Basel, Basel, Switzerland (PMW, AJMW, LAS), Swiss Tropical and Public Health Institute, Basel, Switzerland (CS), Brain Physics Laboratory, Division of Neurosurgery, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK (EB, PS), Department of Anesthesiology, Bluhm Cardiovascular Institute, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA (CWH), Department of Anesthesiology, Perioperative, and Pain Medicine; Division of Cardiac Anesthesia; Stanford University, Stanford, California, USA (CHB), Department of Anaesthesiology and Pain Medicine, Seoul National University, College of Medicine, Seoul, South Korea (YJ), Department of Cardiology and Cardiovascular Research Institute Basel, University Hospital Basel, Basel, Switzerland (CP), Department of Anaesthesiology, Rescue and Pain Medicine, HOCH Health Ostschweiz St. Gallen, St. Gallen, Switzerland (TY), Centre for Laboratory Medicine, St. Gallen, Switzerland (JB, WK), Division of Peri-operative Intensive Care Medicine, HOCH Health Ostschweiz St. Gallen, St. Gallen, Switzerland (CK, UP, MF), Department of Anaesthesiology and Pain Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland (APV).
Christian PuelacherFrom the Anaesthesiology, University Hospital Basel, Basel, Switzerland (PMW, AJMW, ES, ND, LAS), Department of Clinical Research, University of Basel, Basel, Switzerland (PMW, AJMW, LAS), Swiss Tropical and Public Health Institute, Basel, Switzerland (CS), Brain Physics Laboratory, Division of Neurosurgery, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK (EB, PS), Department of Anesthesiology, Bluhm Cardiovascular Institute, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA (CWH), Department of Anesthesiology, Perioperative, and Pain Medicine; Division of Cardiac Anesthesia; Stanford University, Stanford, California, USA (CHB), Department of Anaesthesiology and Pain Medicine, Seoul National University, College of Medicine, Seoul, South Korea (YJ), Department of Cardiology and Cardiovascular Research Institute Basel, University Hospital Basel, Basel, Switzerland (CP), Department of Anaesthesiology, Rescue and Pain Medicine, HOCH Health Ostschweiz St. Gallen, St. Gallen, Switzerland (TY), Centre for Laboratory Medicine, St. Gallen, Switzerland (JB, WK), Division of Peri-operative Intensive Care Medicine, HOCH Health Ostschweiz St. Gallen, St. Gallen, Switzerland (CK, UP, MF), Department of Anaesthesiology and Pain Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland (APV).
Angus J Murgatroyd WilesFrom the Anaesthesiology, University Hospital Basel, Basel, Switzerland (PMW, AJMW, ES, ND, LAS), Department of Clinical Research, University of Basel, Basel, Switzerland (PMW, AJMW, LAS), Swiss Tropical and Public Health Institute, Basel, Switzerland (CS), Brain Physics Laboratory, Division of Neurosurgery, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK (EB, PS), Department of Anesthesiology, Bluhm Cardiovascular Institute, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA (CWH), Department of Anesthesiology, Perioperative, and Pain Medicine; Division of Cardiac Anesthesia; Stanford University, Stanford, California, USA (CHB), Department of Anaesthesiology and Pain Medicine, Seoul National University, College of Medicine, Seoul, South Korea (YJ), Department of Cardiology and Cardiovascular Research Institute Basel, University Hospital Basel, Basel, Switzerland (CP), Department of Anaesthesiology, Rescue and Pain Medicine, HOCH Health Ostschweiz St. Gallen, St. Gallen, Switzerland (TY), Centre for Laboratory Medicine, St. Gallen, Switzerland (JB, WK), Division of Peri-operative Intensive Care Medicine, HOCH Health Ostschweiz St. Gallen, St. Gallen, Switzerland (CK, UP, MF), Department of Anaesthesiology and Pain Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland (APV).
Timur YurttasFrom the Anaesthesiology, University Hospital Basel, Basel, Switzerland (PMW, AJMW, ES, ND, LAS), Department of Clinical Research, University of Basel, Basel, Switzerland (PMW, AJMW, LAS), Swiss Tropical and Public Health Institute, Basel, Switzerland (CS), Brain Physics Laboratory, Division of Neurosurgery, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK (EB, PS), Department of Anesthesiology, Bluhm Cardiovascular Institute, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA (CWH), Department of Anesthesiology, Perioperative, and Pain Medicine; Division of Cardiac Anesthesia; Stanford University, Stanford, California, USA (CHB), Department of Anaesthesiology and Pain Medicine, Seoul National University, College of Medicine, Seoul, South Korea (YJ), Department of Cardiology and Cardiovascular Research Institute Basel, University Hospital Basel, Basel, Switzerland (CP), Department of Anaesthesiology, Rescue and Pain Medicine, HOCH Health Ostschweiz St. Gallen, St. Gallen, Switzerland (TY), Centre for Laboratory Medicine, St. Gallen, Switzerland (JB, WK), Division of Peri-operative Intensive Care Medicine, HOCH Health Ostschweiz St. Gallen, St. Gallen, Switzerland (CK, UP, MF), Department of Anaesthesiology and Pain Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland (APV).
Justus BürgiFrom the Anaesthesiology, University Hospital Basel, Basel, Switzerland (PMW, AJMW, ES, ND, LAS), Department of Clinical Research, University of Basel, Basel, Switzerland (PMW, AJMW, LAS), Swiss Tropical and Public Health Institute, Basel, Switzerland (CS), Brain Physics Laboratory, Division of Neurosurgery, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK (EB, PS), Department of Anesthesiology, Bluhm Cardiovascular Institute, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA (CWH), Department of Anesthesiology, Perioperative, and Pain Medicine; Division of Cardiac Anesthesia; Stanford University, Stanford, California, USA (CHB), Department of Anaesthesiology and Pain Medicine, Seoul National University, College of Medicine, Seoul, South Korea (YJ), Department of Cardiology and Cardiovascular Research Institute Basel, University Hospital Basel, Basel, Switzerland (CP), Department of Anaesthesiology, Rescue and Pain Medicine, HOCH Health Ostschweiz St. Gallen, St. Gallen, Switzerland (TY), Centre for Laboratory Medicine, St. Gallen, Switzerland (JB, WK), Division of Peri-operative Intensive Care Medicine, HOCH Health Ostschweiz St. Gallen, St. Gallen, Switzerland (CK, UP, MF), Department of Anaesthesiology and Pain Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland (APV).
Esther SeebergerFrom the Anaesthesiology, University Hospital Basel, Basel, Switzerland (PMW, AJMW, ES, ND, LAS), Department of Clinical Research, University of Basel, Basel, Switzerland (PMW, AJMW, LAS), Swiss Tropical and Public Health Institute, Basel, Switzerland (CS), Brain Physics Laboratory, Division of Neurosurgery, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK (EB, PS), Department of Anesthesiology, Bluhm Cardiovascular Institute, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA (CWH), Department of Anesthesiology, Perioperative, and Pain Medicine; Division of Cardiac Anesthesia; Stanford University, Stanford, California, USA (CHB), Department of Anaesthesiology and Pain Medicine, Seoul National University, College of Medicine, Seoul, South Korea (YJ), Department of Cardiology and Cardiovascular Research Institute Basel, University Hospital Basel, Basel, Switzerland (CP), Department of Anaesthesiology, Rescue and Pain Medicine, HOCH Health Ostschweiz St. Gallen, St. Gallen, Switzerland (TY), Centre for Laboratory Medicine, St. Gallen, Switzerland (JB, WK), Division of Peri-operative Intensive Care Medicine, HOCH Health Ostschweiz St. Gallen, St. Gallen, Switzerland (CK, UP, MF), Department of Anaesthesiology and Pain Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland (APV).
Nadine DoyleFrom the Anaesthesiology, University Hospital Basel, Basel, Switzerland (PMW, AJMW, ES, ND, LAS), Department of Clinical Research, University of Basel, Basel, Switzerland (PMW, AJMW, LAS), Swiss Tropical and Public Health Institute, Basel, Switzerland (CS), Brain Physics Laboratory, Division of Neurosurgery, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK (EB, PS), Department of Anesthesiology, Bluhm Cardiovascular Institute, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA (CWH), Department of Anesthesiology, Perioperative, and Pain Medicine; Division of Cardiac Anesthesia; Stanford University, Stanford, California, USA (CHB), Department of Anaesthesiology and Pain Medicine, Seoul National University, College of Medicine, Seoul, South Korea (YJ), Department of Cardiology and Cardiovascular Research Institute Basel, University Hospital Basel, Basel, Switzerland (CP), Department of Anaesthesiology, Rescue and Pain Medicine, HOCH Health Ostschweiz St. Gallen, St. Gallen, Switzerland (TY), Centre for Laboratory Medicine, St. Gallen, Switzerland (JB, WK), Division of Peri-operative Intensive Care Medicine, HOCH Health Ostschweiz St. Gallen, St. Gallen, Switzerland (CK, UP, MF), Department of Anaesthesiology and Pain Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland (APV).
Carsten KleinFrom the Anaesthesiology, University Hospital Basel, Basel, Switzerland (PMW, AJMW, ES, ND, LAS), Department of Clinical Research, University of Basel, Basel, Switzerland (PMW, AJMW, LAS), Swiss Tropical and Public Health Institute, Basel, Switzerland (CS), Brain Physics Laboratory, Division of Neurosurgery, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK (EB, PS), Department of Anesthesiology, Bluhm Cardiovascular Institute, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA (CWH), Department of Anesthesiology, Perioperative, and Pain Medicine; Division of Cardiac Anesthesia; Stanford University, Stanford, California, USA (CHB), Department of Anaesthesiology and Pain Medicine, Seoul National University, College of Medicine, Seoul, South Korea (YJ), Department of Cardiology and Cardiovascular Research Institute Basel, University Hospital Basel, Basel, Switzerland (CP), Department of Anaesthesiology, Rescue and Pain Medicine, HOCH Health Ostschweiz St. Gallen, St. Gallen, Switzerland (TY), Centre for Laboratory Medicine, St. Gallen, Switzerland (JB, WK), Division of Peri-operative Intensive Care Medicine, HOCH Health Ostschweiz St. Gallen, St. Gallen, Switzerland (CK, UP, MF), Department of Anaesthesiology and Pain Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland (APV).
Wolfgang KorteFrom the Anaesthesiology, University Hospital Basel, Basel, Switzerland (PMW, AJMW, ES, ND, LAS), Department of Clinical Research, University of Basel, Basel, Switzerland (PMW, AJMW, LAS), Swiss Tropical and Public Health Institute, Basel, Switzerland (CS), Brain Physics Laboratory, Division of Neurosurgery, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK (EB, PS), Department of Anesthesiology, Bluhm Cardiovascular Institute, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA (CWH), Department of Anesthesiology, Perioperative, and Pain Medicine; Division of Cardiac Anesthesia; Stanford University, Stanford, California, USA (CHB), Department of Anaesthesiology and Pain Medicine, Seoul National University, College of Medicine, Seoul, South Korea (YJ), Department of Cardiology and Cardiovascular Research Institute Basel, University Hospital Basel, Basel, Switzerland (CP), Department of Anaesthesiology, Rescue and Pain Medicine, HOCH Health Ostschweiz St. Gallen, St. Gallen, Switzerland (TY), Centre for Laboratory Medicine, St. Gallen, Switzerland (JB, WK), Division of Peri-operative Intensive Care Medicine, HOCH Health Ostschweiz St. Gallen, St. Gallen, Switzerland (CK, UP, MF), Department of Anaesthesiology and Pain Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland (APV).
Urs PietschFrom the Anaesthesiology, University Hospital Basel, Basel, Switzerland (PMW, AJMW, ES, ND, LAS), Department of Clinical Research, University of Basel, Basel, Switzerland (PMW, AJMW, LAS), Swiss Tropical and Public Health Institute, Basel, Switzerland (CS), Brain Physics Laboratory, Division of Neurosurgery, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK (EB, PS), Department of Anesthesiology, Bluhm Cardiovascular Institute, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA (CWH), Department of Anesthesiology, Perioperative, and Pain Medicine; Division of Cardiac Anesthesia; Stanford University, Stanford, California, USA (CHB), Department of Anaesthesiology and Pain Medicine, Seoul National University, College of Medicine, Seoul, South Korea (YJ), Department of Cardiology and Cardiovascular Research Institute Basel, University Hospital Basel, Basel, Switzerland (CP), Department of Anaesthesiology, Rescue and Pain Medicine, HOCH Health Ostschweiz St. Gallen, St. Gallen, Switzerland (TY), Centre for Laboratory Medicine, St. Gallen, Switzerland (JB, WK), Division of Peri-operative Intensive Care Medicine, HOCH Health Ostschweiz St. Gallen, St. Gallen, Switzerland (CK, UP, MF), Department of Anaesthesiology and Pain Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland (APV).
Andreas P VogtFrom the Anaesthesiology, University Hospital Basel, Basel, Switzerland (PMW, AJMW, ES, ND, LAS), Department of Clinical Research, University of Basel, Basel, Switzerland (PMW, AJMW, LAS), Swiss Tropical and Public Health Institute, Basel, Switzerland (CS), Brain Physics Laboratory, Division of Neurosurgery, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK (EB, PS), Department of Anesthesiology, Bluhm Cardiovascular Institute, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA (CWH), Department of Anesthesiology, Perioperative, and Pain Medicine; Division of Cardiac Anesthesia; Stanford University, Stanford, California, USA (CHB), Department of Anaesthesiology and Pain Medicine, Seoul National University, College of Medicine, Seoul, South Korea (YJ), Department of Cardiology and Cardiovascular Research Institute Basel, University Hospital Basel, Basel, Switzerland (CP), Department of Anaesthesiology, Rescue and Pain Medicine, HOCH Health Ostschweiz St. Gallen, St. Gallen, Switzerland (TY), Centre for Laboratory Medicine, St. Gallen, Switzerland (JB, WK), Division of Peri-operative Intensive Care Medicine, HOCH Health Ostschweiz St. Gallen, St. Gallen, Switzerland (CK, UP, MF), Department of Anaesthesiology and Pain Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland (APV).
Miodrag FilipovicFrom the Anaesthesiology, University Hospital Basel, Basel, Switzerland (PMW, AJMW, ES, ND, LAS), Department of Clinical Research, University of Basel, Basel, Switzerland (PMW, AJMW, LAS), Swiss Tropical and Public Health Institute, Basel, Switzerland (CS), Brain Physics Laboratory, Division of Neurosurgery, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK (EB, PS), Department of Anesthesiology, Bluhm Cardiovascular Institute, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA (CWH), Department of Anesthesiology, Perioperative, and Pain Medicine; Division of Cardiac Anesthesia; Stanford University, Stanford, California, USA (CHB), Department of Anaesthesiology and Pain Medicine, Seoul National University, College of Medicine, Seoul, South Korea (YJ), Department of Cardiology and Cardiovascular Research Institute Basel, University Hospital Basel, Basel, Switzerland (CP), Department of Anaesthesiology, Rescue and Pain Medicine, HOCH Health Ostschweiz St. Gallen, St. Gallen, Switzerland (TY), Centre for Laboratory Medicine, St. Gallen, Switzerland (JB, WK), Division of Peri-operative Intensive Care Medicine, HOCH Health Ostschweiz St. Gallen, St. Gallen, Switzerland (CK, UP, MF), Department of Anaesthesiology and Pain Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland (APV).
Luzius A SteinerFrom the Anaesthesiology, University Hospital Basel, Basel, Switzerland (PMW, AJMW, ES, ND, LAS), Department of Clinical Research, University of Basel, Basel, Switzerland (PMW, AJMW, LAS), Swiss Tropical and Public Health Institute, Basel, Switzerland (CS), Brain Physics Laboratory, Division of Neurosurgery, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK (EB, PS), Department of Anesthesiology, Bluhm Cardiovascular Institute, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA (CWH), Department of Anesthesiology, Perioperative, and Pain Medicine; Division of Cardiac Anesthesia; Stanford University, Stanford, California, USA (CHB), Department of Anaesthesiology and Pain Medicine, Seoul National University, College of Medicine, Seoul, South Korea (YJ), Department of Cardiology and Cardiovascular Research Institute Basel, University Hospital Basel, Basel, Switzerland (CP), Department of Anaesthesiology, Rescue and Pain Medicine, HOCH Health Ostschweiz St. Gallen, St. Gallen, Switzerland (TY), Centre for Laboratory Medicine, St. Gallen, Switzerland (JB, WK), Division of Peri-operative Intensive Care Medicine, HOCH Health Ostschweiz St. Gallen, St. Gallen, Switzerland (CK, UP, MF), Department of Anaesthesiology and Pain Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland (APV).
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPeri-operative hypotension is strongly associated with organ injury following noncardiac surgery, however hypotension avoidance trials have not shown meaningful improvements in cardiovascular outcomes and only inconsistent improvements in renal and neurological outcomes. The true haemodynamic drivers of peri-operative organ injury are probably falls in BP below individual autoregulatory boundaries and not below population-based harm thresholds. Novel methods of personalising peri-operative blood pressure (BP) management are needed. Cerebral autoregulation (cAR)-guided precision BP monitoring is an established paradigm that uses near-infrared spectroscopy (NIRS) to noninvasively estimate the safe BP range for the brain and potentially other vital organs. We aim to assess the feasibility and clinical implications of cAR-based precision BP monitoring in major noncardiac surgery.
objectivesTo investigate the association of intra-operative BP excursions below the lower level of cerebral autoregulation, and other measures of disturbed cerebral autoregulatory function, with the primary and secondary outcomes, to determine the feasibility of cAR-based precision BP monitoring in noncardiac surgery.
designMulticentre, prospective cohort study.
setting3 Swiss tertiary care centres. PATIENTS: Inclusion criteria: Adults ≥45 years of age, at cardiovascular risk, undergoing elective major noncardiac surgery with invasive BP monitoring, surgical time ≥90 min, postoperative hospital stay ≥1 night. Exclusion criteria include pregnancy, emergency or urological surgery, glomerular filtration rate <30 ml min PRIMARY OUTCOME MEASURES: Composite of peri-operative myocardial injury and/or peri-operative acute kidney injury on postoperative days 1 to 3. SECONDARY OUTCOMES: Composite of major cardiovascular, renal and neurological complications up to 1 year following surgery: acute coronary syndrome, acute congestive heart failure, coronary revascularisation, stroke, new or progressive chronic kidney disease, new need for renal replacement therapy, all-cause mortality, cardiovascular mortality.
resultsN/A.
conclusionsN/A.
trial registrationAssociation of Intraoperative Blood Pressure Excursions Below Cerebral Autoregulatory Boundaries With Organ Injury Following Major Noncardiac Surgery (AUTOREGULATE-NONCARDIAC), Clinicaltrials.gov NCT05336864. registered 13/04/2022.
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390
Registered trials
NCT05336864ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.