SynthesisActa obstetricia et gynecologica Scandinavica2026
Endometrial microbiota-targeted therapies for chronic endometritis-associated recurrent implantation failure and their impact on IVF outcomes: A systematic review and methodological quality assessment.
Synthesis in Acta obstetricia et gynecologica Scandinavica, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- Embryonic Mediators of Embryo-Uterus Communication, Implantation and Pregnancy.Molecular reproduction and development · 2026Review
- The microbiome research in obstetrics and gynecology is getting attention-Some reasons why.Acta obstetricia et gynecologica Scandinavica · 2026Article
- Decoding the reproductive microbiome: enabling clinical and biological insights through machine and deep learning.Frontiers in endocrinology · 2026Review
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionRecurrent implantation failure (RIF) is a multifactorial reproductive disorder, often associated with chronic endometritis (CE) and alterations of the intrauterine microbiota. MATERIAL AND
methodsThis systematic review evaluated whether microbiota-targeted therapeutic interventions improve pregnancy outcomes in women with CE-associated RIF undergoing in vitro fertilization (IVF)-embryo transfer (ET). Study quality and risk of bias were assessed using the Newcastle-Ottawa Scale (NOS) and the Revised Cochrane Risk of Bias in Non-Randomized Studies - of Interventions (ROBINS-I).
resultsFour studies met the inclusion criteria, encompassing antibiotic, probiotic, and nutraceutical interventions. Considerable heterogeneity was observed in study design, diagnostic criteria, and microbiota assessment methods. Across studies, the reproductive outcomes revealed a clinical pregnancy rate of 50.5% (187/370), ongoing pregnancy rate of 40.1% (107/267), and live birth rate of 41.2% (105/255). Other reported outcomes included seven multiple pregnancies (8.3%), 39 miscarriages (20.0%), 35 biochemical pregnancies (17.9%), and one stillbirth (1.17%).
conclusionsMicrobiota-targeted treatments may improve reproductive outcomes in women with CE-associated RIF; however, the limited number of available studies, small sample sizes, and methodological variability reduce the strength of current evidence. High-quality, prospective, confounder-adjusted trials with rigorous participant selection processes and standardized, validated diagnostic and implementation criteria are needed to confirm these findings and inform clinical practice.
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