Evidence map›Paper›PMID 41684287›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

Dual-Strategy Design of Heterojunction-Enhanced Piezoelectric Hydrogels for Periodontitis Treatment.

Qiangqiang Zhou, Shaojun Fang, Changyi Li, Mengqi Zhou, Xin Sui, Chen Hu, Huaxing Xu, Shiyi Yang, Bing-Qiang Lu, Rongjun Zhang and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Qiangqiang ZhouDepartment of Endodontics, Shanghai Stomatological Hospital and School of Stomatology, Fudan University, Shanghai, China.ORCID 0000-0001-9407-9925
Shaojun FangKey Laboratory of Micro and Nano Photonic Structures (MOE), Shanghai Engineering Research Center of Ultra-Precision Optical Manufacturing, College of Future Information Technology, Fudan University, Shanghai, China.
Changyi LiDepartment of Endodontics, Shanghai Stomatological Hospital and School of Stomatology, Fudan University, Shanghai, China.ORCID 0009-0001-3659-0861
Mengqi ZhouDepartment of Endodontics, Shanghai Stomatological Hospital and School of Stomatology, Fudan University, Shanghai, China.
Xin SuiDepartment of Endodontics, Shanghai Stomatological Hospital and School of Stomatology, Fudan University, Shanghai, China.ORCID 0009-0009-5595-3486
Chen HuDepartment of Endodontics, Shanghai Stomatological Hospital and School of Stomatology, Fudan University, Shanghai, China.
Huaxing XuDepartment of Endodontics, Shanghai Stomatological Hospital and School of Stomatology, Fudan University, Shanghai, China.ORCID 0000-0002-3048-809X
Shiyi YangKey Laboratory of Micro and Nano Photonic Structures (MOE), Shanghai Engineering Research Center of Ultra-Precision Optical Manufacturing, College of Future Information Technology, Fudan University, Shanghai, China.
Bing-Qiang LuDepartment of Endodontics, Shanghai Stomatological Hospital and School of Stomatology, Fudan University, Shanghai, China.ORCID 0000-0002-7027-0351
Rongjun ZhangKey Laboratory of Micro and Nano Photonic Structures (MOE), Shanghai Engineering Research Center of Ultra-Precision Optical Manufacturing, College of Future Information Technology, Fudan University, Shanghai, China.ORCID 0000-0002-1798-9922
Xiaoling WeiDepartment of Endodontics, Shanghai Stomatological Hospital and School of Stomatology, Fudan University, Shanghai, China.ORCID 0000-0001-7327-457X

Funding

and the Shanghai Stomatological Hospital Institutional Projects SHH-2022-YJ-A07and the Shanghai Stomatological Hospital Institutional Projects SSH-2023-01and the Shanghai Stomatological Hospital Institutional Projects SSH-2023-02Shanghai Municipal Health Commission 20254Y0196Shanghai Science and Technology Innovation Action Medical Innovation Research Project 23Y11910100
6 · The paper itself

Abstract

Periodontitis is a widespread chronic inflammatory disease that threatens oral and systemic health by sustaining inflammation and accelerating alveolar bone loss. Although bioelectrical modulation can promote bone repair under inflammatory conditions, the coordinated regulation of electrical signaling, immunoregulation, and osteogenesis within an inflamed microenvironment remains a central challenge. Here, we report a multifunctional piezoelectric hydrogel system that combines heterojunction enhancement with dual-salt synergy. In situ construction of ZnO/ZnS heterojunctions with oxygen vacancies amplifies the piezoelectric output of ZnO, while a polyvinyl alcohol (PVA) multinetwork integrated with magnesium chloride (MgCl

Indexed as

HydrogelsPeriodontitisAnimalsCell DifferentiationHumansOsteogenesisPeriodontal LigamentRatsHydrogelsheterojunctionosteoimmune modulationperiodontal regenerationpiezoelectric hydrogelultrasound stimulation

Identifiers

PMID41684287
PMCPMC13088289

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.