iCARDIO Alliance Global Implementation Guidelines for the Management of Obesity 2025.

There are a number of guidelines on how to manage obesity, but inconsistencies in healthcare access, varying infrastructure, resource constraints and diverse local practices restrict their global applicability. This underscores the need for universal recommendations that address the unique challenges faced by patients and healthcare providers worldwide. Our Global Guidelines emphasise the incorporation of novel therapies while integrating standards of care with the most up-to-date evidence to enable clinicians to optimise obesity management. Context-specific recommendations tailored to individual patient needs are highlighted, providing a thorough evaluation of the risks, benefits and overall value of each therapy, aiming to establish a standard of care that improves patient outcomes and reduces the burden of hospitalisation in this susceptible population. These Global Guidelines provide evidence-based recommendations that represent a group consensus considering the many other published guidelines that have reviewed many of the issues discussed here, but they also make new recommendations where new evidence has recently emerged, and-most importantly-also provide recommendations on several issues where resource limitations may put constraints on the care provided to patients living with obesity. Such 'economic adjustment' recommendations aim to guide situations when 'Resources are somewhat limited' or when 'Resources are severely limited'. Hence, this document presents a comprehensive update to obesity management guidelines, thereby aiming to provide a unified strategy for the pharmacological, non-pharmacological and invasive management of this significant global health challenge that is applicable to the needs of healthcare around the globe.