Evidence map›Paper›PMID 41684198›Full record

ArticleJournal of the American Chemical Society2026

Endogenous Site-Specific Encoding of Trifluoromethyl-Bearing Phenylalanine and Tryptophan for in-Cell

George Augustin, Fatema Bhinderwala, Nathan D Alexander, Iker Hernández, Stanislau Stanisheuski, Christina M Monnie, Alex J Eddins, Yogesh M Gangarde, Vadim A Soloshonok, Mikel Oiarbide and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the American Chemical Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Decoding Galectin-Glycan Recognition withJournal of the American Chemical Society · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

George AugustinDepartment of Biochemistry and Biophysics, 2011 Agricultural and Life Sciences, Oregon State University, Corvallis, Oregon 97331, United States.
Fatema BhinderwalaDepartment of Structural Biology, University of Pittsburgh School of Medicine, 3501 Fifth Ave., Pittsburgh, Pennsylvania 15261, United States.
Nathan D AlexanderDepartment of Biochemistry and Biophysics, 2011 Agricultural and Life Sciences, Oregon State University, Corvallis, Oregon 97331, United States.
Iker HernándezDepartment of Organic Chemistry I, Faculty of Chemistry, University of the Basque Country UPV/EHU, Paseo Manuel Lardizabal 3, 20018 Donostia-San Sebastián, Spain.
Stanislau StanisheuskiDepartment of Biochemistry and Biophysics, 2011 Agricultural and Life Sciences, Oregon State University, Corvallis, Oregon 97331, United States.
Christina M MonnieDepartment of Structural Biology, University of Pittsburgh School of Medicine, 3501 Fifth Ave., Pittsburgh, Pennsylvania 15261, United States.
Alex J EddinsDepartment of Biochemistry and Biophysics, 2011 Agricultural and Life Sciences, Oregon State University, Corvallis, Oregon 97331, United States.
Yogesh M GangardeDepartment of Biochemistry and Biophysics, 2011 Agricultural and Life Sciences, Oregon State University, Corvallis, Oregon 97331, United States.ORCID 0000-0001-9851-1113
Vadim A SoloshonokDepartment of Organic Chemistry I, Faculty of Chemistry, University of the Basque Country UPV/EHU, Paseo Manuel Lardizabal 3, 20018 Donostia-San Sebastián, Spain.
Mikel OiarbideDepartment of Organic Chemistry I, Faculty of Chemistry, University of the Basque Country UPV/EHU, Paseo Manuel Lardizabal 3, 20018 Donostia-San Sebastián, Spain.ORCID 0000-0003-0362-0136
Aitor LandaDepartment of Organic Chemistry I, Faculty of Chemistry, University of the Basque Country UPV/EHU, Paseo Manuel Lardizabal 3, 20018 Donostia-San Sebastián, Spain.ORCID 0000-0001-8574-8568
Richard B CooleyDepartment of Biochemistry and Biophysics, 2011 Agricultural and Life Sciences, Oregon State University, Corvallis, Oregon 97331, United States.ORCID 0000-0003-3928-2757
Angela M GronenbornDepartment of Structural Biology, University of Pittsburgh School of Medicine, 3501 Fifth Ave., Pittsburgh, Pennsylvania 15261, United States.ORCID 0000-0001-9072-3525
Ryan A MehlDepartment of Biochemistry and Biophysics, 2011 Agricultural and Life Sciences, Oregon State University, Corvallis, Oregon 97331, United States.ORCID 0000-0003-2932-4941

Funding

The GCE4All Center: Unleashing the Potential of Genetic Code Expansion for Biomedical ResearchRM1GM144227 · NIGMS · OREGON STATE UNIVERSITY · PI RYAN A MEHL · 2022 to 2026
$6.2M
Ion Mobility Time-of-flight Mass Spectrometry SystemS10RR025628 · NCRR · OREGON STATE UNIVERSITY · PI MAIER, CLAUDIA S, STEVENS, JAN FREDERIK · 2009 to 2009
$440k
NCRR NIH HHS S10 RR025628NIGMS NIH HHS RM1 GM144227
6 · The paper itself

Abstract

Understanding protein structure, dynamics, and interactions in live mammalian cells is essential for elucidating cellular mechanisms in health and disease. Here, we report genetic code expansion (GCE) systems that enable efficient site-specific incorporation of trifluoromethylphenylalanine (tfmF) and trifluoromethyltryptophan (tfmW) into mammalian proteins. While tfmF has previously been encoded in

Identifiers

PMID41684198
PMCPMC12951447

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.