Sputum Biomarkers of Inflammation to Track Acute Respiratory Events in School-Age Children with Cystic Fibrosis.

Elad Ben-Meir, Lucy Perrem, Gyde Nissen, Michelle Shaw, Felix Ratjen, Hartmut Grasemann

Abstract readObservational Study

In one paragraph

Observational study in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Elad Ben-MeirPediatric Pulmonary Unit, Hadassah Medical Center, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem 91120, Israel.ORCID 0000-0003-4032-1039

Lucy PerremDivision of Respiratory Medicine, Children's Health Ireland, University College Dublin, D01 YC67 Dublin, Ireland .

Gyde NissenDepartment of Paediatrics, University Hospital Schleswig-Holstein, University of Lübeck, 23562 Lübeck, Germany.

Michelle ShawDivision of Respiratory Medicine, Department of Paediatrics, The Hospital for Sick Children, Toronto, ON M5G 1E8, Canada.ORCID 0000-0002-0966-6779

Felix RatjenDivision of Respiratory Medicine, Department of Paediatrics, The Hospital for Sick Children, Toronto, ON M5G 1E8, Canada.ORCID 0000-0003-4057-6592

Hartmut GrasemannDivision of Respiratory Medicine, Department of Paediatrics, The Hospital for Sick Children, Toronto, ON M5G 1E8, Canada.ORCID 0000-0003-0331-9642

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cystic fibrosis (CF) is characterized by neutrophil-driven airway inflammation and acute respiratory events (AREs) that contribute to progressive lung damage. AREs are clinically heterogeneous and often occur without measurable changes in lung function. This study aimed to evaluate the utility of molecular airway inflammatory markers for detecting AREs in school-age children with CF. We performed a secondary analysis of a prospective observational study of children with CF (ages 6.7-16.8 years) followed for two years. Sputum samples were collected from 50 participants during stable visits and AREs. Concentrations of 14 inflammatory cytokines were measured using ELISA and multiplex assays. Associations with lung function (ppFEV

Indexed as

BiomarkersCystic FibrosisInflammationSputumAdolescentChildCytokinesFemaleHumansMaleProspective StudiesRespiratory Function TestsBiomarkersCytokinesacute respiratory eventsairway inflammationbiomarkerscalprotectincystic fibrosiscytokinesIL-1 pathwayneutrophilic inflammation

Identifiers

PMID41684034

DOI10.3390/ijms27031616

PMCPMC12898048

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.