Evidence map›Paper›PMID 41683969›Full record

ArticleInternational journal of molecular sciences2026

Activation of the S100A8/A9 Alarmin Amplifies Inflammatory Pathways in Equine Ascending Placentitis.

Kirsten E Scoggin, Shimaa I Rakha, Ahmed M Abdellatif, Fatma Adlan, Yosra A Helmy, Rebecca Ruby, Barry Ball, Yatta Boakari, Hossam El-Sheikh Ali

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Kirsten E ScogginMaxwell H. Gluck Equine Research Center, Department of Veterinary Science, University of Kentucky, Lexington, KY 40546, USA.ORCID 0000-0003-1348-641X
Shimaa I RakhaDepartment of Theriogenology, Faculty of Veterinary Medicine, Mansoura University, Mansoura 35516, Egypt.
Ahmed M AbdellatifDepartment of Anatomy and Embryology, Faculty of Veterinary Medicine, Mansoura University, Mansoura 35516, Egypt.ORCID 0000-0001-9235-2449
Fatma AdlanDepartment of Theriogenology, Faculty of Veterinary Medicine, Mansoura University, Mansoura 35516, Egypt.
Yosra A HelmyMaxwell H. Gluck Equine Research Center, Department of Veterinary Science, University of Kentucky, Lexington, KY 40546, USA.ORCID 0000-0003-1470-5418
Rebecca RubyVeterinary Diagnostic Laboratory, University of Kentucky, Lexington, KY 40511, USA.
Barry BallMaxwell H. Gluck Equine Research Center, Department of Veterinary Science, University of Kentucky, Lexington, KY 40546, USA.ORCID 0000-0002-0502-0276
Yatta BoakariDepartment of Large Animal Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Texas A & M University, College Station, TX 77843, USA.ORCID 0000-0001-9130-4752
Hossam El-Sheikh AliMaxwell H. Gluck Equine Research Center, Department of Veterinary Science, University of Kentucky, Lexington, KY 40546, USA.ORCID 0000-0003-1677-488X

Funding

2024 Equine Research Award - Boehringer Ingelheim N/AGluck Equine Research Foundation N/AUSDA Capacity Project HATCH #7009671
6 · The paper itself

Abstract

Ascending placentitis is a significant cause of equine pregnancy loss, yet the upstream inflammatory triggers are poorly defined. Recently, we identified S100A8/S100A9 (S100A8/A9) alarmins as potential upstream regulators in a chronic equine placentitis model. The current study aimed to determine whether this upregulation is sustained in the acute model and in clinical cases, and to elucidate the expression of their downstream inflammatory mediators. Using an experimental model, we quantified

Indexed as

AlarminsCalgranulin ACalgranulin BHorse DiseasesInflammationPlacenta DiseasesStreptococcal InfectionsAnimalsFemaleHorsesPlacentaPregnancySignal TransductionStreptococcus equiAlarminsCalgranulin ACalgranulin Balarmin S100A8/S100A9calgranulinschorioallantoisequineplacentitisS100 proteins

Identifiers

PMID41683969
PMCPMC12897833

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.