Evidence map›Paper›PMID 41683963›Full record

ArticleInternational journal of molecular sciences2026

Uncovering a Glaucoma-Linked Lysophosphatidic Acid-MAPK/AP-1 Fibrosis Axis in Human Trabecular Meshwork Cells and Its Modulation by

Youngsic Jeon, Hyukjoon Kwon, Hong Ryul Ahn, Gyuwon Huh, Taejung Kim, Young-Tae Park, Hyun Bong Park, Jin-Hyoung Jeong, Jae-Hyun Jo, Young-Joo Kim and 1 more

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Youngsic JeonCenter for Natural Product Efficacy Optimization, Korea Institute of Science and Technology (KIST), Gangneung Institute of Natural Products, Gangneung 25451, Republic of Korea.ORCID 0000-0002-5673-5036
Hyukjoon KwonCenter for Natural Product Efficacy Optimization, Korea Institute of Science and Technology (KIST), Gangneung Institute of Natural Products, Gangneung 25451, Republic of Korea.
Hong Ryul AhnCenter for Natural Product Efficacy Optimization, Korea Institute of Science and Technology (KIST), Gangneung Institute of Natural Products, Gangneung 25451, Republic of Korea.ORCID 0009-0005-7429-3656
Gyuwon HuhR&D Center, NovMetaPharma Co., Ltd., Seoul 06050, Republic of Korea.ORCID 0009-0005-4760-018X
Taejung KimCenter for Natural Product Efficacy Optimization, Korea Institute of Science and Technology (KIST), Gangneung Institute of Natural Products, Gangneung 25451, Republic of Korea.ORCID 0000-0002-9449-4763
Young-Tae ParkCenter for Natural Product Efficacy Optimization, Korea Institute of Science and Technology (KIST), Gangneung Institute of Natural Products, Gangneung 25451, Republic of Korea.ORCID 0000-0003-1787-1577
Hyun Bong ParkDepartment of Biology, College of Natural Sciences, Gangneung-Wonju National University, Gangneung 25457, Republic of Korea.
Jin-Hyoung JeongDepartment of Healthcare Management, Catholic Kwandong University, Gangneung 25601, Republic of Korea.ORCID 0009-0004-7273-7279
Jae-Hyun JoDepartment of Digital Healthcare, Catholic Kwandong University, Gangneung 25601, Republic of Korea.
Young-Joo KimCenter for Natural Product Efficacy Optimization, Korea Institute of Science and Technology (KIST), Gangneung Institute of Natural Products, Gangneung 25451, Republic of Korea.ORCID 0000-0003-1080-0581
Sang Hoon JungCenter for Natural Product Efficacy Optimization, Korea Institute of Science and Technology (KIST), Gangneung Institute of Natural Products, Gangneung 25451, Republic of Korea.

Funding

Korea Institute of Science and Technology 26Z0031Korea Institute of Science and Technology 2E33531Ministry of Education (MOE) and the Gangwon State (G.S.) 2025-RISE-10-001Ministry of Education (MOE) and the Gangwon State (G.S.) 2025-RISE-10-005
6 · The paper itself

Abstract

Dysregulated extracellular matrix (ECM) deposition and epithelial-mesenchymal transition (EMT) in the trabecular meshwork (TM) contribute to glaucoma-associated fibrotic remodeling, and lysophosphatidic acid (LPA) potently induces these profibrotic responses in human trabecular meshwork (HTM) cells. We investigated whether an ethanolic extract of

Indexed as

DiospyrosGlaucomaLysophospholipidsPlant ExtractsTrabecular MeshworkTranscription Factor AP-1Cell MovementExtracellular MatrixFibrosisHumansPlant LeavesSignal Transductionlysophosphatidic acidLysophospholipidsPlant ExtractsTranscription Factor AP-1Diospyros kakiextracellular matrixglaucomaMAPK signalingtrabecular meshwork

Identifiers

PMID41683963
PMCPMC12898371

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.