Evidence map›Paper›PMID 41683962›Full record

ArticleInternational journal of molecular sciences2026

Targeting Pediatric Glioblastomas by Combining OLIG2 Inhibitor CT-179 with Fractionated Radiation in a Panel of Patient-Derived Orthotopic Xenograft Mouse Models.

Holly Lindsay, Yuchen Du, Lin Qi, Huiyuan Zhang, Sibo Zhao, Frank K Braun, Mari Kogiso, Clifford Stephan, Gordon Alton, Gregory Stein and 10 more

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Holly LindsayTexas Children's Cancer Center, Texas Children's Hospital, Baylor College of Medicine, Houston, TX 77030, USA.
Yuchen DuTexas Children's Cancer Center, Texas Children's Hospital, Baylor College of Medicine, Houston, TX 77030, USA.
Lin QiTexas Children's Cancer Center, Texas Children's Hospital, Baylor College of Medicine, Houston, TX 77030, USA.ORCID 0000-0003-2491-2701
Huiyuan ZhangTexas Children's Cancer Center, Texas Children's Hospital, Baylor College of Medicine, Houston, TX 77030, USA.
Sibo ZhaoTexas Children's Cancer Center, Texas Children's Hospital, Baylor College of Medicine, Houston, TX 77030, USA.ORCID 0009-0003-6401-7186
Frank K BraunTexas Children's Cancer Center, Texas Children's Hospital, Baylor College of Medicine, Houston, TX 77030, USA.ORCID 0000-0002-5514-1412
Mari KogisoTexas Children's Cancer Center, Texas Children's Hospital, Baylor College of Medicine, Houston, TX 77030, USA.
Clifford StephanHealth Science Center, Texas A & M University, Houston, TX 77843, USA.ORCID 0000-0003-0657-6484
Gordon AltonCurtana Pharmaceuticals, Inc., Austin, TX 78759, USA.
Gregory SteinCurtana Pharmaceuticals, Inc., Austin, TX 78759, USA.
Graham BeatonCurtana Pharmaceuticals, Inc., Austin, TX 78759, USA.
Santosh KesariCurtana Pharmaceuticals, Inc., Austin, TX 78759, USA.ORCID 0000-0003-3772-6000
Steve NeuhauserPIVOT Coordinating Center, The Jackson Laboratory, Bar Harbor, ME 04609, USA.ORCID 0000-0002-2993-9324
Tim StearnsPIVOT Coordinating Center, The Jackson Laboratory, Bar Harbor, ME 04609, USA.ORCID 0000-0002-5533-6076
Jeff ChuangPIVOT Coordinating Center, The Jackson Laboratory, Bar Harbor, ME 04609, USA.
Emily L JocoyPIVOT Coordinating Center, The Jackson Laboratory, Bar Harbor, ME 04609, USA.
Carol J BultPIVOT Coordinating Center, The Jackson Laboratory, Bar Harbor, ME 04609, USA.ORCID 0000-0001-9433-210X
Beverly TeicherNational Cancer Institute, Bethesda, MD 20892, USA.ORCID 0000-0003-1535-7304
Malcolm A SmithNational Cancer Institute, Bethesda, MD 20892, USA.
Xiao-Nan LiTexas Children's Cancer Center, Texas Children's Hospital, Baylor College of Medicine, Houston, TX 77030, USA.ORCID 0000-0002-6719-3789

Funding

Pediatric Oncology In Vivo Testing Program Coordinating CenterU24CA263963 · NCI · JACKSON LABORATORY · PI CAROL J BULT, Jeffrey Hsu-Min Chuang · 2021 to 2026
$4.7M
Matching panels of in vivo and in vitro model system of pediatric brain tumorsU01CA217613 · NCI · LURIE CHILDREN'S HOSPITAL OF CHICAGO · PI LI, XIAONAN · 2020 to 2024
$2.9M
NCI NIH HHS U01 CA217613NCI NIH HHS U24 CA263963NIH/NCI U01 CA217613 (Li XN) , 2UO1 CA199288-06 (LI XN)
6 · The paper itself

Abstract

The poor clinical outcomes of pediatric high-grade glioma (pHGG) highlight the urgent need for new therapies. Oligodendrocyte lineage transcription factor 2 (

Indexed as

Brain NeoplasmsGlioblastomaOligodendrocyte Transcription Factor 2AnimalsCell Line, TumorCell SurvivalChildDose Fractionation, RadiationFemaleHumansMaleMiceXenograft Model Antitumor AssaysOLIG2 protein, humanOligodendrocyte Transcription Factor 2GBMOLIG2PDOXpediatric brain tumorradiationtherapeutic efficacy

Identifiers

PMID41683962
PMCPMC12898090

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.