Evidence map›Paper›PMID 41683953›Full record

ArticleInternational journal of molecular sciences2026

Synthesis, Structural Studies, and Biological Evaluation of Copper(I) and Copper(II) Complexes Supported by Bis(pyrazol-1-yl)acetate Ligand Functionalized with Amantadine for the Treatment of Glioblastoma.

Sofia Migani, Giuseppina Bozzuto, Annarica Calcabrini, Marisa Colone, Maria Luisa Dupuis, Miriam Caviglia, Cristina Aguzzi, Maria Beatrice Morelli, Fabio Del Bello, Wilma Quaglia and 8 more

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Sofia MiganiSchool of Science and Technology, Chemistry Division, University of Camerino, via Madonna delle Carceri (ChIP), 62032 Camerino, Italy.
Giuseppina BozzutoNational Center for Drug Research and Evaluation, Italian National Institute of Health, Viale Regina Elena 299, 00161 Roma, Italy.ORCID 0000-0002-9761-3326
Annarica CalcabriniNational Center for Drug Research and Evaluation, Italian National Institute of Health, Viale Regina Elena 299, 00161 Roma, Italy.ORCID 0000-0002-9600-1117
Marisa ColoneNational Center for Drug Research and Evaluation, Italian National Institute of Health, Viale Regina Elena 299, 00161 Roma, Italy.ORCID 0000-0002-7522-7483
Maria Luisa DupuisNational Center for Drug Research and Evaluation, Italian National Institute of Health, Viale Regina Elena 299, 00161 Roma, Italy.ORCID 0000-0002-6051-8261
Miriam CavigliaSchool of Science and Technology, Chemistry Division, University of Camerino, via Madonna delle Carceri (ChIP), 62032 Camerino, Italy.ORCID 0009-0006-2522-6569
Cristina AguzziSchool of Pharmacy, Immunopathology and Molecular Medicine Unit, University of Camerino, via Madonna delle Carceri 9, 62032 Camerino, Italy.ORCID 0000-0002-8508-6389
Maria Beatrice MorelliSchool of Pharmacy, Immunopathology and Molecular Medicine Unit, University of Camerino, via Madonna delle Carceri 9, 62032 Camerino, Italy.ORCID 0000-0002-4614-5649
Fabio Del BelloSchool of Pharmacy, Medicinal Chemistry Unit, University of Camerino, via Madonna delle Carceri (ChIP), 62032 Camerino, Italy.ORCID 0000-0001-6538-6029
Wilma QuagliaSchool of Pharmacy, Medicinal Chemistry Unit, University of Camerino, via Madonna delle Carceri (ChIP), 62032 Camerino, Italy.
Maura PelleiSchool of Science and Technology, Chemistry Division, University of Camerino, via Madonna delle Carceri (ChIP), 62032 Camerino, Italy.ORCID 0000-0001-5020-1730
Carlo SantiniSchool of Science and Technology, Chemistry Division, University of Camerino, via Madonna delle Carceri (ChIP), 62032 Camerino, Italy.ORCID 0000-0002-3942-1713
Chiara BattocchioDepartment of Science, Roma Tre University, Via della Vasca Navale 79, 00146 Roma, Italy.ORCID 0000-0003-4590-0865
Giovanna IucciDepartment of Science, Roma Tre University, Via della Vasca Navale 79, 00146 Roma, Italy.ORCID 0000-0002-6478-3759
Iole VendittiDepartment of Science, Roma Tre University, Via della Vasca Navale 79, 00146 Roma, Italy.ORCID 0000-0002-9306-573X
Carlo MeneghiniDepartment of Science, Roma Tre University, Via della Vasca Navale 79, 00146 Roma, Italy.ORCID 0000-0003-4846-8422
Simone AmatoriDepartment of Science, Roma Tre University, Via della Vasca Navale 79, 00146 Roma, Italy.ORCID 0000-0002-3310-9796
Annarita StringaroNational Center for Drug Research and Evaluation, Italian National Institute of Health, Viale Regina Elena 299, 00161 Roma, Italy.ORCID 0000-0002-0143-2978

Funding

NextGenerationEU MUR-Fondo Promozione e Sviluppo - D.M. 737/2021, INVIRCuM, University of Camerino, FAR 2022 PNRNextGenerationEU NGEU PNRR, D.M. n. 351/2022 M4C1 I4.1.NextGenerationEU Prin 2022 Prot: 2022488T5S
6 · The paper itself

Abstract

This paper reports the synthesis, structural characterization, and biological evaluation of a novel series of Cu

Indexed as

AmantadineAntineoplastic AgentsCoordination ComplexesCopperGlioblastomaPyrazolesApoptosisCell Line, TumorHumansLigandsReactive Oxygen SpeciesAmantadineAntineoplastic AgentsCoordination ComplexesCopperLigandsPyrazolesReactive Oxygen Speciesamantadine-conjugated ligandscoppercytotoxicityglioblastomamicroscopy analysesphosphanesspectroscopySR-XPSXAS

Identifiers

PMID41683953
PMCPMC12898142

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.