Histological and Genetic Markers of Cellular Senescence in Keratinocyte Cancers and Actinic Keratosis: A Systematic Review.

Piotr Sobolewski, Mateusz Koper, Anna Wasaznik-Jedras, Malgorzata Kolos, Irena Walecka

Abstract readSystematic Review

In one paragraph

Synthesis in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Piotr SobolewskiDermatology Clinic, National Medical Institute of the Ministry of Interior and Administration, 02-507 Warsaw, Poland.ORCID 0000-0002-3775-8021

Mateusz KoperChair and Clinic of Dermatology and Pediatric Dermatology, Centre of Postgraduate Medical Education, 02-507 Warsaw, Poland.

Anna Wasaznik-JedrasPathomorphological Center, National Institute of Medicine of the Ministry of Interior and Administration, 02-507 Warsaw, Poland.

Malgorzata KolosPathomorphological Center, National Institute of Medicine of the Ministry of Interior and Administration, 02-507 Warsaw, Poland.

Irena WaleckaDermatology Clinic, National Medical Institute of the Ministry of Interior and Administration, 02-507 Warsaw, Poland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cellular senescence is a stress-induced cell-cycle arrest that constrains expansion of ultraviolet-damaged keratinocytes yet can remodel the microenvironment. This systematic review evaluated histological and genetic or epigenetic senescence markers in actinic keratosis (AK), cutaneous squamous cell carcinoma (cSCC), and basal cell carcinoma (BCC). PubMed, Scopus, and Web of Science were searched (January 2005-May 2025); 34 human studies were included. AK showed an early senescent signature with frequent cyclin-dependent kinase inhibitor p21 (p21CIP1) expression (82.1%) and DNA damage signaling, including phosphorylated histone H2AX (gamma-H2AX) positivity (77%). In invasive cSCC, p21

Indexed as

Basal Cell CarcinomaCellular SenescenceKeratinocytesKeratosis, ActinicSkin NeoplasmsBiomarkers, TumorCarcinoma, Squamous CellCutaneous Squamous Cell CarcinomaDNA DamageHumansBiomarkers, Tumoractinic keratosisbasal cell carcinomacellular senescencecutaneous squamous cell carcinomasenescence biomarkers

Identifiers

PMID41683940

DOI10.3390/ijms27031520

PMCPMC12898786

What OpenQuestion holds

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LicenceCC BY

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.