Evidence map›Paper›PMID 41683916›Full record

ArticleInternational journal of molecular sciences2026

Single-Cell Mapping Reveals MIF-Centered Immunoregulatory Networks in Colorectal Cancer.

Marios Gkoris, Ilias Georgakopoulos-Soares, Apostolos Zaravinos

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Marios GkorisDepartment of Life Sciences, School of Sciences, European University Cyprus, Nicosia 1516, Cyprus.
Ilias Georgakopoulos-SoaresDepartment of Life Sciences, School of Sciences, European University Cyprus, Nicosia 1516, Cyprus.
Apostolos ZaravinosDepartment of Life Sciences, School of Sciences, European University Cyprus, Nicosia 1516, Cyprus.ORCID 0000-0003-4625-5562

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Colorectal cancer (CRC) progression is strongly shaped by the tumor microenvironment (TME), where complex interactions between epithelial, immune, and stromal cells orchestrate immune suppression and tumor evolution. To dissect these relationships at single-cell resolution, we analyzed CRC scRNA-seq datasets using Seurat for data integration and CellChat for ligand-receptor inference. We identified extensive cellular heterogeneity within the TME, dominated by CMS2/CMS3 epithelial states, SPP1

Indexed as

Colorectal NeoplasmsIntramolecular OxidoreductasesMacrophage Migration-Inhibitory FactorsSingle-Cell AnalysisAntigens, Differentiation, B-LymphocyteGene Expression Regulation, NeoplasticHistocompatibility Antigens Class IIHumansHyaluronan ReceptorsMacrophagesReceptors, CXCR4Signal TransductionSingle-Cell Gene Expression AnalysisTumor MicroenvironmentAntigens, Differentiation, B-LymphocyteHistocompatibility Antigens Class IIHyaluronan ReceptorsIntramolecular Oxidoreductasesinvariant chainMacrophage Migration-Inhibitory FactorsMIF protein, humanReceptors, CXCR4cell communicationcolorectal cancerscRNA-seqtumor microenvironment

Identifiers

PMID41683916
PMCPMC12897769

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.