Evidence map›Paper›PMID 41683897›Full record

ArticleInternational journal of molecular sciences2026

A Hydrolase-Rich Venom Beyond Neurotoxins: Integrative Functional Proteomic and Immunoreactivity Analyses Reveal Novel Peptides in the Amazonian Scorpion

Gisele Adriano Wiezel, Karla de Castro Figueiredo Bordon, Jonas Gama Martins, Viviane Imaculada do Carmo Custódio, Alessandra Kimie Matsuno, Rudi Emerson de Lima Procópio, Eliane Candiani Arantes

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Gisele Adriano WiezelDepartment of BioMolecular Sciences, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Ribeirão Preto 14040-903, SP, Brazil.ORCID 0000-0001-9791-0630
Karla de Castro Figueiredo BordonDepartment of BioMolecular Sciences, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Ribeirão Preto 14040-903, SP, Brazil.ORCID 0000-0001-6540-2295
Jonas Gama MartinsGraduate Program in Genetics, Conservation and Evolutionary Biology (PPG GCBEv), National Institute for Amazon Research (INPA), Manaus 69067-375, AM, Brazil.
Viviane Imaculada do Carmo CustódioDepartment of Pediatrics, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto 14049-900, SP, Brazil.
Alessandra Kimie MatsunoDepartment of Pediatrics, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto 14049-900, SP, Brazil.ORCID 0000-0002-3491-1641
Rudi Emerson de Lima ProcópioGraduate Program in Biotechnology and Natural Resources of Amazon, University of the State of Amazonas (UEA), Manaus 69065-001, AM, Brazil.ORCID 0000-0002-8538-4642
Eliane Candiani ArantesDepartment of BioMolecular Sciences, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Ribeirão Preto 14040-903, SP, Brazil.ORCID 0000-0002-6712-6033

Funding

Fundação de Amparo à Pesquisa do Estado de São Paulo 2021/11936-3Fundação de Amparo à Pesquisa do Estado de São Paulo 2023/01083-9Fundação de Amparo à Pesquisa do Estado de São Paulo 2024/10051-6Fundação de Amparo à Pesquisa do Estado de São Paulo 2024/10128-9Fundação de Amparo à Pesquisa do Estado de São Paulo 2024/10138-4Fundação de Amparo à Pesquisa do Estado de São Paulo 2024/10953-0Fundação de Amparo à Pesquisa do Estado de São Paulo 2024/16842-5Fundação de Amparo à Pesquisa do Estado de São Paulo 2025/01816-1Fundação de Amparo à Pesquisa do Estado do Amazonas FAPEAM-POSGRAD 353/2023
6 · The paper itself

Abstract

The scorpion family Buthidae, renowned for its neurotoxin-rich venoms, dominates toxinology, while non-buthid venoms remain largely unexplored. Here, we present a comprehensive proteomic and biochemical characterization of the Amazonian chactid scorpion

Indexed as

NeurotoxinsPeptidesProteomicsScorpionsScorpion VenomsAmino Acid SequenceAnimalsMetalloproteasesPhospholipases A2ProteolysisTandem Mass SpectrometryMetalloproteasesNeurotoxinsPeptidesPhospholipases A2Scorpion VenomsAmazonian scorpionbioactive peptidesbiotechnological potentialcross-reactivitydrug discoveryhyaluronidaseintegrative venomicsphospholipase A2venom evolution

Identifiers

PMID41683897
PMCPMC12897845

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.