Evidence map›Paper›PMID 41683889›Full record

ArticleInternational journal of molecular sciences2026

Loss of Hepatocyte FOXA3 Improves MASH and Atherosclerosis in Hyperlipidemic Ldlr-Deficient Mice.

Hui Wang, Shuwei Hu, Jiayou Wang, Raja Gopoju, Li Lin, Lakshitha Gunawardana, Xinwen Wang, Liya Yin, Yanqiao Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Hui WangDepartment of Internal Medicine and the Translational Cardiovascular Research Center, University of Arizona College of Medicine-Phoenix, Phoenix, AZ 85004, USA.
Shuwei HuDepartment of Internal Medicine and the Translational Cardiovascular Research Center, University of Arizona College of Medicine-Phoenix, Phoenix, AZ 85004, USA.
Jiayou WangDepartment of Internal Medicine and the Translational Cardiovascular Research Center, University of Arizona College of Medicine-Phoenix, Phoenix, AZ 85004, USA.
Raja GopojuDepartment of Internal Medicine and the Translational Cardiovascular Research Center, University of Arizona College of Medicine-Phoenix, Phoenix, AZ 85004, USA.
Li LinDepartment of Pharmaceutical Sciences, Northeast Ohio Medical University, Rootstown, OH 44272, USA.
Lakshitha GunawardanaDepartment of Internal Medicine and the Translational Cardiovascular Research Center, University of Arizona College of Medicine-Phoenix, Phoenix, AZ 85004, USA.
Xinwen WangDepartment of Pharmaceutical Sciences, Northeast Ohio Medical University, Rootstown, OH 44272, USA.
Liya YinDepartment of Internal Medicine and the Translational Cardiovascular Research Center, University of Arizona College of Medicine-Phoenix, Phoenix, AZ 85004, USA.ORCID 0000-0001-7825-9539
Yanqiao ZhangDepartment of Internal Medicine and the Translational Cardiovascular Research Center, University of Arizona College of Medicine-Phoenix, Phoenix, AZ 85004, USA.

Funding

Forkhead Box A3 and Bile Acid MetabolismR01DK121548 · NIDDK · UNIVERSITY OF ARIZONA · PI ZHANG, YANQIAO · 2020 to 2023
$2.1M
Hepatic FOXA3 Links NAFLD to AtherosclerosisR01DK118805 · NIDDK · NORTHEAST OHIO MEDICAL UNIVERSITY · PI ZHANG, YANQIAO · 2019 to 2022
$2.0M
Hepatocyte FOXA3 in Alcohol-Associated Liver DiseaseR01AA032555 · NIAAA · UNIVERSITY OF ARIZONA · PI Yanqiao Zhang · 2025 to 2026
$1.3M
NIAAA NIH HHS R01 AA032555NIDDK NIH HHS R01 DK118805NIDDK NIH HHS R01 DK121548NIH HHS 1R01DK118805-04NIH HHS 1R01DK121548-04
6 · The paper itself

Abstract

Forkhead box protein A3 (FOXA3), also known as hepatocyte nuclear factor 3g (HNF3g), is a member of the FOX family of transcription factors and regulates lipid and glucose metabolism and liver regeneration. Hepatic FOXA3 is reduced in obesity and patients with metabolic dysfunction-associated steatohepatitis (MASH). So far, it remains unknown whether hepatic FOXA3 is essential for regulating lipid metabolism or metabolic dysfunction-associated liver disease (MASLD). In this study, we first investigated whether genetic inactivation of hepatocyte

Indexed as

AtherosclerosisFatty LiverHepatocyte Nuclear Factor 3-gammaHepatocytesHyperlipidemiasReceptors, LDLAnimalsDiet, WesternDisease Models, AnimalLipid MetabolismLiverMaleMiceMice, Inbred C57BLMice, KnockoutFoxa3 protein, mouseHepatocyte Nuclear Factor 3-gammaReceptors, LDLatherosclerosisbile acidslipogenesisliverMASLD

Identifiers

PMID41683889
PMCPMC12898518

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.