Evidence map›Paper›PMID 41683886›Full record

ArticleInternational journal of molecular sciences2026

Cytokine Dynamics in Severe COVID-19 vs. Influenza A Elderly Patients: A Prospective Comparative Study.

Mihai Aronel Rus, Adina Huțanu, Daniel Corneliu Leucuța, Violeta Tincuța Briciu, Monica Iuliana Muntean, Angela Ionică, Mihaela Sorina Lupșe

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Mihai Aronel RusDepartment of Infectious Diseases, "Iuliu Hatieganu" University of Medicine and Pharmacy, Iuliu Moldovan Street, no 23, 400348 Cluj-Napoca, Romania.ORCID 0009-0006-8531-3146
Adina HuțanuDepartment of Laboratory Medicine, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Târgu Mureș, 540142 Targu Mures, Romania.ORCID 0000-0001-9798-1594
Daniel Corneliu LeucuțaDepartment of Medical Informatics and Biostatistics, Iuliu Hatieganu University of Medicine and Pharmacy, Pasteur Street, no 6, 400349 Cluj-Napoca, Romania.ORCID 0000-0003-4218-8622
Violeta Tincuța BriciuDepartment of Infectious Diseases, "Iuliu Hatieganu" University of Medicine and Pharmacy, Iuliu Moldovan Street, no 23, 400348 Cluj-Napoca, Romania.
Monica Iuliana MunteanDepartment of Infectious Diseases, "Iuliu Hatieganu" University of Medicine and Pharmacy, Iuliu Moldovan Street, no 23, 400348 Cluj-Napoca, Romania.ORCID 0000-0002-1288-3918
Angela IonicăClinical Hospital for Infectious Diseases, Iuliu Moldovan Street, no 23, 400348 Cluj-Napoca, Romania.ORCID 0000-0002-1438-2498
Mihaela Sorina LupșeDepartment of Infectious Diseases, "Iuliu Hatieganu" University of Medicine and Pharmacy, Iuliu Moldovan Street, no 23, 400348 Cluj-Napoca, Romania.

Funding

Iuliu Hațieganu University of Medicine and Pharmacy Institutional Program for Doctoral Research
6 · The paper itself

Abstract

COVID-19 and influenza A (FluA) cause severe respiratory infections in elderly patients, with cytokine dysregulation playing a central role. Direct comparative data in older adults remains limited. We aimed to characterize cytokine dynamics and their prognostic value in hospitalized elderly patients with COVID-19 vs. FluA. We performed a prospective cohort study including adults ≥ 60 years hospitalized with respiratory failure due to COVID-19 or FluA between March 2023 and March 2024. Serum IL-1β, IL-6, IL-10, IL-17A, IL-34, MCP-1, and CXCL10 were measured on Day 1 and Day 5 of hospitalization using Luminex

Indexed as

COVID-19CytokinesInfluenza, HumanAgedAged, 80 and overChemokine CCL2FemaleHumansInfluenza A virusMaleMiddle AgedProspective StudiesSARS-CoV-2Chemokine CCL2CytokinesCOVID-19cytokinesinfluenza ALuminex

Identifiers

PMID41683886
PMCPMC12898413

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.